S0645
Anti-Sodium Channel PN1 antibody produced in rabbit
affinity isolated antibody, lyophilized powder
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About This Item
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
rat
technique(s)
western blot (chemiluminescent): 1:200-1:400
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... SCN9A(6335)
rat ... Scn9a(78956)
General description
Sodium channel protein type 9 subunit alpha (SCN9A) is encoded in human chromosome location 2q24.3. SCN9A is also called the Nav1.7. Sodium channel protein type 9 subunit alpha, (SCN9A) encodes nine isoforms in human and they are majorly expressed in cells of peripheral nervous system.
Immunogen
synthetic peptide corresponding to amino acids 446-460 of rat PN1 (with additional N-terminal cysteine). This epitope is highly conserved in rabbit and human.
Biochem/physiol Actions
They function to generate and conduct electrical impulses in neuronal membranes. SCNA9 mutations is associated with epilepsy in infant dravet syndrome. Nonsense mutations in SCNA9 gene leads to loss sensation towards pain. Missense mutations in SCNA9 results in primary erythermalgia and paroxysmal extreme pain disorder.
Physical form
Lyophilized from a solution containing phosphate buffered saline, pH 7.4, 1% bovine serum albumin, and 0.05% sodium azide.
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Find documentation for the products that you have recently purchased in the Document Library.
From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels
Catterall WA
Neuron, 26(1), 13-25 (2000)
p. L1612P, a novel voltage-gated sodium channel Nav1. 7 mutation inducing a cold sensitive paroxysmal extreme pain disorder
Suter MR, et al.
Anesthesiology, 122(2), 414-423 (2015)
Structural basis of Nav1. 7 inhibition by an isoform-selective small-molecule antagonist
Ahuja S, et al.
Science, 350(6267), aac5464-aac5464 (2015)
International union of pharmacology. xlvii. Nomenclature and structure-function relationships of voltage-gated sodium channels
Catterall WA, et al.
Pharmacological Reviews, 57(6267), 397-409 (2005)
Epilepsy phenotype associated with a chromosome 2q24. 3 deletion involving SCN1A: Migrating partial seizures of infancy or atypical Dravet syndrome
Lim B, et al.
Epilepsy Research, 109, 34-39 (2015)
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