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S0508

Sigma-Aldrich

Sulfamonomethoxine

Synonym(s):

4-Amino-N-(6-methoxy-4-pyrimidinyl)benzenesulfonamide, 4-Methoxy-6-sulfanilamidopyrimidine, N1-(6-Methoxy-4-pyrimidinyl)sulfanilamide, SMM

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About This Item

Empirical Formula (Hill Notation):
C11H12N4O3S
CAS Number:
1220-83-3
Molecular Weight:
280.30
Beilstein/REAXYS Number:
621128
MDL number:
MFCD00063466
UNSPSC Code:
51283946
PubChem Substance ID:
24899439
NACRES:
NA.85

form

powder

Quality Level

200

color

white to yellow-white

solubility

methanol: soluble 10 mg/mL

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria
parasites

mode of action

DNA synthesis | interferes
enzyme | inhibits

SMILES string

COc1cc(NS(=O)(=O)c2ccc(N)cc2)ncn1

InChI

1S/C11H12N4O3S/c1-18-11-6-10(13-7-14-11)15-19(16,17)9-4-2-8(12)3-5-9/h2-7H,12H2,1H3,(H,13,14,15)

InChI key

WMPXPUYPYQKQCX-UHFFFAOYSA-N

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Related Categories

General description

Chemical structure: sulfonamide

Application

Sulfamonomethoxine is used to study degradation by Fe3O4 magnetic nanoparticles. It is used in blood kinetic studies and is used to study capsule formation of Bordetella bronchiseptica.

Biochem/physiol Actions

Sulfamonomethoxine is a competitive inhibitor of dihydropteroate synthetase used to block the synthesis of folic acid.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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C Girardi et al.
Pharmacological research, 22(2), 79-86 (1990-03-01)
Intrauterine administration was performed in six Friesan cows with a disposable spray preparation containing 3 g of sulfamonomethoxine and 3 g of oxytetracycline, in order to investigate their serum kinetics. Sulfamonomethoxine levels were determined by a reversed-phase HPLC method, whilst
Thomas Trolle et al.
Bioinformatics (Oxford, England), 31(13), 2174-2181 (2015-02-27)
Numerous in silico methods predicting peptide binding to major histocompatibility complex (MHC) class I molecules have been developed over the last decades. However, the multitude of available prediction tools makes it non-trivial for the end-user to select which tool to
A Kuwano
Zentralblatt fur Veterinarmedizin. Reihe B. Journal of veterinary medicine. Series B, 38(9), 685-688 (1991-11-01)
Bordetella bronchiseptica phase I organism possesses a capsule and has the ability to agglutinate with K antiserum, although phase III organism lacks both. The present study examines the effect of sulfamonomethoxine (SMMX) on capsule formation of B. bronchiseptica. I also
G Zhang et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 25(4), 413-423 (2008-03-19)
A rapid lateral flow immunoassay screening method has been developed for the determination of sulfamonomethoxine (SMM) residues in swine urine. For this purpose, a specific monoclonal antibody (mAb), SMM4B9 for SMM, was generated and characterized. The mAb showed low cross-reactivity
Depletion rate of N4-acetylsulphamonomethoxine in tissues of laying hens.
N Furusawa
Veterinary journal (London, England : 1997), 157(1), 103-105 (1999-02-25)
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