Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

View All Documentation

S0145

Sigma-Aldrich

[D-Pro2, D-Trp7,9]-Substance P acetate salt

≥97% (HPLC)

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C74H106N20O13S · xC2H4O2
Molecular Weight:
1515.82 (free base basis)
MDL number:
MFCD00237268
UNSPSC Code:
12352200
PubChem Substance ID:
24899430

Product Name

[D-Pro2, D-Trp7,9]-Substance P acetate salt, ≥97% (HPLC)

assay

≥97% (HPLC)

storage temp.

−20°C

SMILES string

CC(O)=O.CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]6CCCN6C(=O)[C@H](CCCCN)NC(=O)[C@H]7CCCN7C(=O)[C@@H](N)CCCNC(N)=N)C(N)=O

InChI

1S/C74H106N20O13S.C2H4O2/c1-42(2)36-55(66(100)85-51(63(79)97)30-35-108-3)89-68(102)58(39-45-41-84-50-22-10-8-19-47(45)50)92-67(101)56(37-43-16-5-4-6-17-43)90-69(103)57(38-44-40-83-49-21-9-7-18-46(44)49)91-65(99)52(26-28-61(77)95)86-64(98)53(27-29-62(78)96)87-70(104)60-25-15-34-94(60)73(107)54(23-11-12-31-75)88-71(105)59-24-14-33-93(59)72(106)48(76)20-13-32-82-74(80)81;1-2(3)4/h4-10,16-19,21-22,40-42,48,51-60,83-84H,11-15,20,23-39,75-76H2,1-3H3,(H2,77,95)(H2,78,96)(H2,79,97)(H,85,100)(H,86,98)(H,87,104)(H,88,105)(H,89,102)(H,90,103)(H,91,99)(H,92,101)(H4,80,81,82);1H3,(H,3,4)/t48-,51-,52-,53-,54-,55-,56-,57+,58+,59+,60-;/m0./s1

InChI key

VVOKNUZJEDEUTC-GDSHFHCJSA-N

Amino Acid Sequence

Arg-Pro-Lys-Pro-Gln-Gln-Trp-Phe-Trp-Leu-Met-NH2

Biochem/physiol Actions

Substance P antagonist

Linkage

Similar to S 4509, but produced by Sigma.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
041H58103

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Sara Calatayud et al.
Naunyn-Schmiedeberg's archives of pharmacology, 367(1), 51-55 (2003-03-05)
The effects of endotoxin on fecal pellet output and the neural mechanisms involved in this response were investigated in conscious rats. E. coli endotoxin (40 micro g/kg i.p.) significantly increased fecal excretion for 3 h after the injection. Water content
Analgesic effect of antagonists of substance P.
F Lembeck et al.
Biochemical and biophysical research communications, 103(4), 1318-1321 (1981-12-31)
Ping Lin et al.
Sheng li xue bao : [Acta physiologica Sinica], 61(4), 331-338 (2009-08-25)
The aim of this study was to, from the point of neurogenic inflammation, explore the pathogenesis of colitis and to provide direct evidence for the neurogenic colitis hypothesis. Male Sprague-Dawley rats (180-220 g) anesthetized with chloral hydrate were intrathecally (ith)
A synthetic peptide as an antagonist of substance P.
G Engberg et al.
Nature, 293(5829), 222-223 (1981-09-17)
Arati Prabhu et al.
Peptides, 26(5), 875-885 (2005-04-06)
Substance P (SP) is an important neuropeptide involved in pain transmission and induction of inflammation. Its antagonists are being extensively investigated for their non-narcotic analgesic and anti-inflammatory activity. With a view towards better understanding the structural requirements of these analogs

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service