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S009

Sigma-Aldrich

LY-165,163

solid

Synonym(s):

4-[2-[4-[3-(Trifluoromethyl)phenyl]-1-piperazinyl]ethyl]benzeneamine, p-Aminophenethyl-m-trifluoromethylphenyl piperazine, PAPP

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25 MG
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About This Item

Empirical Formula (Hill Notation):
C19H22F3N3
CAS Number:
1814-64-8
Molecular Weight:
349.39
MDL number:
MFCD00055098
UNSPSC Code:
12352202
PubChem Substance ID:
24278123
NACRES:
NA.77

$110.00

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form

solid

Quality Level

100

color

off-white

solubility

0.1 M HCl: slightly soluble
H2O: insoluble
ethanol: freely soluble

SMILES string

Nc1ccc(CCN2CCN(CC2)c3cccc(c3)C(F)(F)F)cc1

InChI

1S/C19H22F3N3/c20-19(21,22)16-2-1-3-18(14-16)25-12-10-24(11-13-25)9-8-15-4-6-17(23)7-5-15/h1-7,14H,8-13,23H2

InChI key

GAAKALASJNGQKD-UHFFFAOYSA-N

Gene Information

human ... HTR1A(3350) , HTR1D(3352)

Biochem/physiol Actions

Selective 5-HT1A serotonin receptor agonist and 5-HT1D serotonin receptor antagonist.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
038H4680

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P H Hutson et al.
European journal of pharmacology, 138(2), 215-223 (1987-06-19)
1-[2-(4-aminophenyl)ethyl]-4-(3-trifluoromethylphenyl)piperazine (LY 165163, PAPP) (1 mg/kg s.c.) significantly decreased 5-hydroxytryptophan (5-HTP) accumulation in cortex, hippocampus, striatum, septum, pons + medulla and midbrain and increased DOPA accumulation in the cortex and striatum following inhibition of aromatic amino acid decarboxylase with NSD
K J Simansky et al.
The Journal of pharmacology and experimental therapeutics, 247(3), 1073-1081 (1988-12-01)
This investigation evaluated the effects of the 1-arylpiperazines (1-(1-naphthyl)piperazine (1-NP), 1-(2-[4-aminophenylethyl]-4-[3-trifluoromethylphenyl]piperazine (PAPP), 1-(3-trifluoromethylphenyl)piperazine (TFMPP) and 1-(3-chlorophenyl)piperazine (mCPP) on head-twitching elicited by central 5-hydroxytryptamine2, (5-HT2) agonists and on the 5-HT motor syndrome associated with stimulating 5-HT1A receptors in rodents. 1-NP (0.25-16.0
R W Ransom et al.
Journal of neurochemistry, 46(1), 68-75 (1986-01-01)
1-[2-(4-Aminophenyl)ethyl]-4-(3-trifluoromethylphenyl)piperazine (PAPP) inhibits [3H]5-hydroxytryptamine (5-HT, serotonin) binding to 5-HT1A and 5-HT1B sites in rat brain with apparent equilibrium dissociation constants (KD) of 2.9 and 328 nM, respectively. [3H]PAPP was synthesized, its binding to central serotonin receptors was examined, and its
Kosuke Ino et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 35(1), 39-43 (2018-10-03)
Tissue engineering requires analytical methods to monitor cell activity in hydrogels. Here, we present a method for the electrochemical imaging of cell activity in hydrogels embedded in printed polycaprolactone (PCL) scaffolds. Because a structure made of only hydrogel is fragile
J S Sprouse et al.
Synapse (New York, N.Y.), 1(1), 3-9 (1987-01-01)
A direct comparison was made of the effects of serotonin 5-HT1A and 5-HT1B selective compounds on the spontaneous firing rate of dorsal raphe serotoninergic neurons in chloral-hydrate-anesthetized rats. Following intravenous administration, the 5-HT1A selective compounds ipsapirone (TVX Q 7821) and
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