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RAB1046

Sigma-Aldrich

Human FGF-21 ELISA Kit

for cell culture supernatants, plasma, and serum samples

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96 WELLS
$674.00

$674.00


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96 WELLS
$674.00

About This Item

UNSPSC Code:
41116158
NACRES:
NA.32

$674.00


Usually ships in 1 week. (Orders outside of US and Europe, please allow an additional 1-2 weeks for delivery)

Notify Me

Get notified when this item is ready to ship via email.

species reactivity

human

packaging

kit of 96 wells (12 strips x 8 wells)

technique(s)

ELISA: suitable

input

sample type plasma
sample type cell culture supernatant(s)
sample type serum sample(s)

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 8 pg/ml

detection method

colorimetric

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... FGF21(26291)

Application

For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.

Biochem/physiol Actions

Fibroblast growth factor 21 (FGF-21) plays a vital role in the regulation of glucose uptake in mouse 3T3-L1 and primary human adipocytes.[1] In addition, it is also implicated in lipid metabolism and in energy balance.[2] FGF-21 plays a key role in controlling oxidative stress cell response. Overexpression of the gene has been associated with the development of acute pancreatitis, obesity, insulin resistance and metabolic syndrome.[2] Additionally, elevated expression of FGF-21 has been observed in patients with insulin resistance and type 2 diabetes mellitus (T2DM). Thus, it can be considered as a potent target for an effective treatment of diabetes.[1][3]

Other Notes

A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.

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Corrosion

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Warning

hcodes

Hazard Classifications

Met. Corr. 1

Storage Class

8A - Combustible corrosive hazardous materials

flash_point_f

Not applicable

flash_point_c

Not applicable


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FGF-21 as a novel metabolic regulator
Kharitonenkov A, et al.
The Journal of Clinical Investigation, 1627-35 null
Circulating FGF-21 Levels in Normal Subjects and in Newly Diagnose Patients with Type 2 Diabetes Mellitus
Chen WW, et al.
Experimental and Clinical Endocrinology & Diabetes, 65-8 null
Fibroblast growth factor 21 and its novel association with oxidative stress.
Gomez-Samano M A, et al.
Redox Biology, 335-341 null

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