The standard used in the Human Uromodulin ELISA (RAB0751) is full length native human Uromodulin, which has been isolated from human urine. Its purity is greater than 95% as determined by SDS-PAGE.
RAB0751
Human UMOD / Uromodulin ELISA Kit
Synonym(s):
THP, Tamm-Horsfall protein, Tamm-Horsfall urinary glycoprotein, Uromodulin
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96 WELLS
$815.00
$815.00
Usually Ships in 4 Weeks. (Orders outside of US, please allow an additional 1-2 weeks for delivery)
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96 WELLS
$815.00
About This Item
UNSPSC Code:
41116158
NACRES:
NA.84
$815.00
Usually Ships in 4 Weeks. (Orders outside of US, please allow an additional 1-2 weeks for delivery)
Recommended Products
species reactivity
human
packaging
kit of 96 wells (12 strips x 8 wells)
technique(s)
ELISA: suitable
input
sample type serum
sample type plasma
sample type cell culture supernatant(s)
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 40 pg/mL
standard curve range: 40.96-10000 pg/mL
detection method
colorimetric
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... UMOD(7369)
General description
The UMOD ELISA kit provides for the Quantitative measurement of Uromodulin in Cell Culture Supernatants, Plasma and Serum.
Uromodulin also known as Tamm-Horsfall protein (THP) is a glycoprotein localized in the thick ascending limb (TAL) of the Henle loop in the kidney.[1] It is the most abundant protein excreted in the urine.[2] Uromodulin plays a role in preventing urinary tract infections and kidney stones. It aids in immunomodulation and regulation of ion transport in TAL.[2] Uromodulin acts as an inverse biomarker in the early detection of chronic kidney disorders.[1]
Application
For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Human UMOD / Uromodulin ELISA Kit has been used to measure the levels of Tamm-Horsfall protein (THP) in human plasma samples.[1]
Other Notes
A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.
Please type the word sample in the text box provided for lot number.
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Warning
hcodes
pcodes
Hazard Classifications
Met. Corr. 1
Storage Class
8A - Combustible corrosive hazardous materials
flash_point_f
Not applicable
flash_point_c
Not applicable
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Olivier Devuyst et al.
Nature reviews. Nephrology, 13(9), 525-544 (2017-08-07)
Uromodulin (also known as Tamm-Horsfall protein) is exclusively produced in the kidney and is the most abundant protein in normal urine. The function of uromodulin remains elusive, but the available data suggest that this protein might regulate salt transport, protect
Kaice A LaFavers et al.
Science translational medicine, 11(512) (2019-10-04)
High serum concentrations of kidney-derived protein uromodulin [Tamm-Horsfall protein (THP)] have recently been shown to be independently associated with low mortality in both older adults and cardiac patients, but the underlying mechanism remains unclear. Here, we show that THP inhibits
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Is the standard utilized in the Human Uromodulin ELISA (RAB0751) of native or recombinant origin? Also, is the standard full length, and what was the method of purification used?
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