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species reactivity
human
packaging
kit of 96 wells (12 strips x 8 wells)
technique(s)
ELISA: suitable
input
sample type serum
sample type plasma
sample type cell culture supernatant(s)
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 61 pg/mL
standard curve range: 61.44-15000 pg/mL
detection method
colorimetric
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... APOE(348)
General description
The ApoE2 ELISA kit provides for the quantitative measurement of ApoE2 in cell culture supernatants, plasma and serum.
The APOE gene is mapped to human chromosome 19q13.32 and codes for a 299 amino acid protein.[1][2] The APOE protein is localised to the brain and liver. In the central nervous system, APOE is mostly produced by astrocytes and neurons to a lesser extent.[1]
The APOE gene is mapped to human chromosome 19q13.32 and codes for a 299 amino acid protein.[1][2] The APOE protein is localised to the brain and liver. In the central nervous system, APOE is mostly produced by astrocytes and neurons to a lesser extent.[1]
Application
For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Biochem/physiol Actions
APOE is responsible for the translocation of cholesterol and phospholipids to the cells. APOE is known to be associated with neuroinflammatory and neurodegenerative diseases.[1] APOE regulates cognitive behaviour, and hence related to neurocognitive disorders that are influenced by HIV infection or Alzheimer′s disease.[1][3]
signalword
Warning
hcodes
pcodes
Hazard Classifications
Met. Corr. 1
Storage Class
8A - Combustible corrosive hazardous materials
flash_point_f
Not applicable
flash_point_c
Not applicable
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Hippocampal synaptic and neural network deficits in young mice carrying the human APOE4 gene.
Sun G Z, et al.
CNS Neuroscience & Therapeutics, 23(9), 748-758 (2017)
Apolipoprotein E4 Suppresses Neuronal-Specific Gene Expression in Maturing Neuronal Progenitor Cells Exposed to HIV.
Geffin R, et al.
Journal of Neuroimmune Pharmacology, 12(3), 462-483 (2017)
Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study.
Ridker PM et al
American Journal of Human Genetics, 82(5), 1185-1192 (2008)
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