RAB0282

Equine Interleukin-1 Receptor Antagonist / IL-1F3 ELISA Kit

for serum, plasma and cell culture supernatant

• Synonym(s): IL-1ra
• UNSPSC Code: 12352200
• NACRES: NA.32

Properties

• species reactivity: equine
• packaging: kit of 96 wells (12 strips x 8 wells)
• technique(s): ELISA: suitable; capture ELISA: suitable
• input: sample type cell culture supernatant(s); sample type serum; sample type plasma
• assay range: inter-assay cv: <12%; intra-assay cv: <10%; sensitivity: 10 pg/mL; standard curve range: 12.29-3000 pg/mL
• detection method: colorimetric
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: equine ... IL1RN(100034236)

Description

General description

The Equine IL-1ra (interleukin 1 receptor antagonist) ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of equine IL-1ra in serum, plasma, cell culture supernatants and urine.

Immunogen

Recombinant Equine IL-1 Receptor Antagonist

Application

For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)

Biochem/physiol Actions

Interleukin-1 receptor antagonist (IL-1RA) inhibits the activity of IL-1α and IL-1β by competitively binding to their type I and type II receptors. IL-1RA plays a vital role in inhibition of acute pro-inflammatory response and forbidding chronic inflammation from damaging healthy tissues. Abnormal expression of IL-1RA leads to development of inflammatory or autoimmune related diseases.[1] Allelic polymorphism of IL-1Rα leads to inflammatory bowel disease (IBD).[2] Therapeutically, IL-1Rα may help in the treatment of sepsis, rheumatoid arthritis, asthma.[3][4][5] Overexpression of IL-1Rα is observed in serum of psoriatic arthritis (PsA) patients.[6]

Other Notes

A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.

Kit Components Also Available Separately

• RABELADB ELISA 5X Assay/Sample Diluent Buffer B (Item E1)
• RABELADC ELISA 1X Assay/Sample Diluent Buffer C (Item L)
• RABSTOP3 ELISA Stop Solution (Item I)
• RABTMB3 ELISA Colorimetric TMB Reagent (HRP Substrate, Item H)
• RABWASH4 20X Wash Buffer (Item B)

Safety Information

• pictograms: GHS05
• signalword: Warning
• hcodes: H290
• pcodes: P234 - P390
• Hazard Classifications: Met. Corr. 1
• Storage Class: 8A - Combustible corrosive hazardous materials