R8782

Ro4368554

≥98% (HPLC)

• Synonym(s): 3-benzenesulfonyl-7-(4-methyl-piperazin-1-yl)-1H-indole, 7-(4-methyl-1-piperazinyl)-3-(phenylsulfonyl)-1H-Indole
• Empirical Formula (Hill Notation): C₁₉H₂₁N₃O₂S
• CAS Number: 478082-99-4
• Molecular Weight: 355.45
• MDL number: MFCD16875430
• UNSPSC Code: 12352202
• PubChem Substance ID: 329824040

Properties

• assay: ≥98% (HPLC)
• form: powder
• color: off-white
• solubility: DMSO: >10 mg/mL
• originator: Roche
• Storage temp.: room temp
• SMILES string: CN1CCN(CC1)c2cccc3c(c[nH]c23)S(=O)(=O)c4ccccc4
• InChI: 1S/C19H21N3O2S/c1-21-10-12-22(13-11-21)17-9-5-8-16-18(14-20-19(16)17)25(23,24)15-6-3-2-4-7-15/h2-9,14,20H,10-13H2,1H3
• Inchi Key: AOPYPEADLGTXRA-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Ro4368554 is a 5-HT6 receptor antagonist.

Ro4368554 is a 5-HT6 receptor antagonist. RO4368554 acts selectively at 5-HT6 receptors where it binds with a greater than 100-fold selectivity over other monoamine receptor subtypes (-log M pKi = 9.4 at 5-HT6 and 7.1 at 5-HT2A).

Features and Benefits

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Pictograms: GHS07
• signalword: Warning
• hcodes: H302
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable