The previously assigned protein identifier P01912 has been merged into P01911. Full details can be found on the UniProt database.
Specificity
Recognizes HLA-DR, a product of the human major histocompatibility complex. The antibody is specific for a non-polymorphic HLA-DR determinant.
Immunogen
GM-1500 human tumor cell line
Target description
HLA-DR is located on chromosome 6. It is composed of a heavy and light chain, which are two non-covalently associated subunits of molecular weight 33-36 kDa and 24-30 kDa, respectively. These class II antigens are expressed primarily on B cells, and on monocytes and activated T cells, and function in cell-cell recognition in regulation of the immune response.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide
Preparation Note
Quantum Red is a tandem fluorescent dye created by coupling R-phycoerythrin with Cy5 reactive dye. This red dye is efficiently excited at 488 nm and emits at 670 nm.
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Texas Red is a registered trademark of Life Technologies
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Low-grade systemic inflammation associated to obesity leads to cardiovascular complications, caused partly by infiltration of adipose and vascular tissue by effector T cells. The signals leading to T cell differentiation and tissue infiltration during obesity are poorly understood. We tested whether saturated
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