R6275
Anti-phospho-Retinoblastoma (pSer780) antibody produced in rabbit
affinity isolated antibody, buffered aqueous glycerol solution
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About This Item
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous glycerol solution
species reactivity
mouse, human, rat
technique(s)
western blot (chemiluminescent): 1:1,000 using human fibroblasts synchronized by serum deprivation
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pSer780)
Gene Information
human ... RB1(5925)
mouse ... Rb1(19645)
rat ... Rb1(24708)
General description
RB1 (RB transcriptional corepressor 1) codes for nuclear phosphoprotein pRB (retinoblastoma protein). It is located on human chromosome 13q14. It is a tumor-suppressor gene.
Specificity
Recognizes Rb phosphorylated at Ser780 and does not react with non-phosphorylated Rb. Does not react with Rb phosphorylated at other sites.
Immunogen
synthetic peptide corresponding to residues around pSer780 of the human retinoblastoma tumor suppressor protein (Rb).
Biochem/physiol Actions
RB1 (RB transcriptional corepressor 1) plays an important role throughout G1/S phase transition. Absence of RB induces prostate cancer metastasis. It plays an important role in modulating the cell cycle. It also regulates cell stemness and differentiation.
Physical form
Solution in 10 mM sodium HEPES, pH 7.5, containing 150 mM sodium chloride, 100 μg/ml bovine serum albumin, and 50% glycerol.
Preparation Note
Purified using protein A and affinity chromatography.
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Storage Class
10 - Combustible liquids
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A Parent-of-Origin Effect Impacts the Phenotype in Low Penetrance Retinoblastoma Families Segregating the c.1981C>T/p.Arg661Trp Mutation of RB1
Eloy P, et al.
PLoS Genetics, 12(2) (2016)
Alessandro Poli et al.
Journal of cellular physiology, 232(9), 2550-2557 (2016-10-13)
Phosphatidylinositol (PI) signaling is an essential regulator of cell motility and proliferation. A portion of PI metabolism and signaling takes place in the nuclear compartment of eukaryotic cells, where an array of kinases and phosphatases localize and modulate PI. Among
Do MRPS18-2 and RB proteins cooperate to control cell stemness and differentiation, preventing cancer development
Kashuba E and Mushtaq M
Experimental Oncology, 39(1), 12-16 (2017)
RB Loss Promotes Prostate Cancer Metastasis
Thangavel C, et al.
Cancer Research, 77(4), 982-995 (2017)
The Prognostic Value of the Immunohistochemical Expression of Phosphorylated RB and p16 Proteins in Association with Cyclin D1 and the p53 Pathway in a Large Cohort of Patients with Breast Cancer Treated with Taxane-based Adjuvant Chemotherapy
Gavressea T, et al.
Anticancer Research, 37(6), 2947-2957 (2017)
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