Rin/Rit2 (Ras-like without CAAX 2) belongs to the Ras superfamily of small guanosine triphosphatases. In human, it is expressed in several neurons whereas in mouse, it is expressed in the ganglion cell layer and inner nuclear layer of the retina. It is located on human chromosome 18q12.3.
Immunogen
recombinant human Rin.
Biochem/physiol Actions
Aberrations in Rin/Rit2 (Ras-like without CAAX 2) causes parkinson′s disease. It participates in neurotrophin signaling. It trigger ERK (extracellular signal-regulated kinase) and p38 MAP (mitogen-activated protein) kinase signaling to promote differentiation.
Physical form
Solution in 20 mM sodium phosphate, 150 mM sodium chloride, 50% glycerol, and 3 mM sodium azide.
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RIT2 polymorphism is associated with Parkinson's disease in a Han Chinese population
Nie K, et al.
Neurobiology of Aging, 36(3) (2015)
RIT2, a neuron-specific small guanosine triphosphatase, is expressed in retinal neuronal cells and its promoter is modulated by the POU4 transcription factors
Zhang L,et al.
Molecular Vision, 19, 1371-1386 (2013)
Rin GTPase couples nerve growth factor signaling to p38 and b-Raf/ERK pathways to promote neuronal differentiation
Shi GX, et al.
The Journal of Biological Chemistry, 280(45), 37599-37609 (2005)
Ras-like without CAAX 2 (RIT2), a member of the Ras superfamily of small guanosine triphosphatases, is involved in regulating neuronal function. RIT2 is a unique member of the Ras family in that RIT2 is preferentially expressed in various neurons, including
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