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R4278

Sigma-Aldrich

Anti-phospho-Retinoblastoma (pSer811) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-phospho-Rb (pSer811)

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About This Item

MDL number:
MFCD06411917
UNSPSC Code:
12352203
NACRES:
NA.41

$808.00

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biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

rat, mouse, human

technique(s)

western blot: 0.5-1.5 μg/mL using Jurkat cells in high growth phase.

UniProt accession no.

P06400

shipped in

dry ice

storage temp.

−70°C

target post-translational modification

phosphorylation (pSer811)

Gene Information

human ... RB1(5925)
mouse ... Rb1(19645)
rat ... Rb1(24708)

General description

Retinoblastoma (Rb) is a pediatric intraocular neoplasm caused due to the biallelic inactivation of the RB1 gene. Retinoblastoma is also known as RB1 (RB transcriptional corepressor 1). It is located on human chromosome 13q14. It is a tumor suppressor gene.

Immunogen

synthetic phosphopeptide derived from the region of human Rb that contains Ser811.

Biochem/physiol Actions

Retinoblastoma (RB) interacts with several protein factors to control the expression of target genes which promote cell cycle arrest, apoptosis, and differentiation. It helps to modulate nucleosome and chromatin structures. Absence of RB induces prostate cancer metastasis.

Physical form

Solution in Dulbecco′s phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, with 1.0 mg/mL BSA (IgG and protease free) and 0.05% sodium azide.

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Storage Class

10 - Combustible liquids

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Certificates of Analysis (COA)

Lot/Batch Number
044K1445

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A Parent-of-Origin Effect Impacts the Phenotype in Low Penetrance Retinoblastoma Families Segregating the c.1981C>T/p.Arg661Trp Mutation of RB1
Eloy P, et al.
PLoS Genetics, 12(2) (2016)
Roles of pRB in the Regulation of Nucleosome and Chromatin Structures
Uchida C, et al.
BioMed Research International (2016)
Patrick J Cimino et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 27(8), 1073-1087 (2014-01-11)
Merkel cell carcinoma is a highly aggressive cutaneous neuroendocrine tumor that has been associated with Merkel cell polyomavirus in up to 80% of cases. Merkel cell polyomavirus is believed to influence pathogenesis, at least in part, through expression of the
RB Loss Promotes Prostate Cancer Metastasis
Thangavel C, et al.
Cancer Research, 77(4), 982-995 (2017)

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