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R3778

Sigma-Aldrich

Anti-phospho-Retinoblastoma (pSer807) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-phospho-Rb (pSer807)

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About This Item

MDL number:
MFCD06411895
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

western blot: 0.25-0.75 μg/mL using Jurkat cells in high growth phase.

UniProt accession no.

P06400

shipped in

dry ice

storage temp.

−70°C

target post-translational modification

phosphorylation (pSer807)

Gene Information

human ... RB1(5925)

General description

RB1 (RB transcriptional corepressor 1) codes for nuclear phosphoprotein pRB (retinoblastoma protein). It is located on chromosome 13q14. It is a tumor-suppressor gene.

Immunogen

synthetic phosphopeptide derived from the region of human Rb that contains Ser807.

Biochem/physiol Actions

RB1 (RB transcriptional corepressor 1) plays an important role throughout G1/S phase transition. Absence of RB induces prostate cancer metastasis. It plays an important role in modulating the cell cycle. It also regulates cell stemness and differentiation.

Physical form

Solution in phosphate buffer, pH 7.4, containing 1 mg/mL BSA (protease and IgG-free) and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

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Certificates of Analysis (COA)

Lot/Batch Number
044K1335

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A Parent-of-Origin Effect Impacts the Phenotype in Low Penetrance Retinoblastoma Families Segregating the c.1981C>T/p.Arg661Trp Mutation of RB1
Eloy P, et al.
PLoS Genetics, 12(2) (2016)
Do MRPS18-2 and RB proteins cooperate to control cell stemness and differentiation, preventing cancer development
Kashuba E and Mushtaq M
Experimental Oncology, 39(1), 12-16 (2017)
RB Loss Promotes Prostate Cancer Metastasis
Thangavel C, et al.
Cancer Research, 77(4), 982-995 (2017)
The Prognostic Value of the Immunohistochemical Expression of Phosphorylated RB and p16 Proteins in Association with Cyclin D1 and the p53 Pathway in a Large Cohort of Patients with Breast Cancer Treated with Taxane-based Adjuvant Chemotherapy
Gavressea T, et al.
Anticancer Research, 37(6), 2947-2957 (2017)

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