GRK1 (rhodopsin kinase) is an enzyme that belongs to serine/threonine protein kinase family and expresses mainly in rod and cone photoreceptors. It has a crucial role in phosphorylation of photoactivated rhodopsin and hence starting steps in its deactivation. Monoclonal anti-rhodopsin kinase 1a antibody can be used in immunoprecipitation. Mouse anti-rhodopsin kinase 1a antibody reacts specifically with an epitope present in the C-terminal region of mouse, bovine, rat, chicken and human GRK1a. The product has shown no cross-reactivity with other G protein coupled kinases together with GRK1b.
Immunogen
derived from human GRK1
Application
Monoclonal anti-rhodopsin kinase 1a antibody can be used in indirect immunofluorescence and western blotting.
Target description
Rhodopsin Kinase 1A encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation.
Physical form
Supplied in phosphate buffered saline containing 0.05% sodium azide.
The G protein-coupled receptor kinases (GRKs) are important enzymes in the desensitization of activated G protein-coupled receptors (GPCR). Seven members of the GRK family have been identified to date. Among these enzymes, GRK1 is involved in phototransduction and is the
The Journal of biological chemistry, 273(9), 5124-5131 (1998-03-28)
The G protein-coupled receptor kinases (GRKs) are critical enzymes in the desensitization of activated G protein-coupled receptors. Six members of the GRK family have been identified to date. Among these enzymes, GRK1 (rhodopsin kinase) is involved in phototransduction and is
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