R2905

Anti-RAE1 (C-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

• Synonym(s): Anti-MRNP41, Anti-RNA export 1, Anti-mRNA-binding protein 41 kDa
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 43 kDa
• species reactivity: human, mouse, rat
• concentration: ~1.0 mg/mL
• technique(s): western blot: 1-2 μg/mL using 3T3 and RIN5 cell lysates; western blot: 2-4 μg/mL using HEK-293T cell lysate
• UniProt accession no.: P78406
• shipped in: dry ice
• storage temp.: −20°C
• Gene Information: human ... RAE1(8480) ; mouse ... Rae1(66679) ; rat ... Rae1(362281)

Description

General description

RAE1 (mRNA export factor 1) is a nucleic acid-binding protein. It is also called as Gle2 (RNA export factor) or mrnp41 (mRNA binding protein mrnp 41).[1] It is located on human chromosome 20q13.[2]

Immunogen

synthetic peptide corresponding to amino acids 349-366 of human RAE1, conjugated to KLH via an N-terminal added cysteine residue. The corresponding sequence is identical in rat and mouse.

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Biochem/physiol Actions

Suppression of RAE1 (mRNA export factor 1) affects the mitotic spindle assembly.[3] It involves in mRNA export as mRNP-interacting protein.[4] In mouse, Rae1 is necessary for early embryogenesis.[5]

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)