R2274
RANTES from mouse
>95% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
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About This Item
MDL number:
UNSPSC Code:
51111800
biological source
mouse
recombinant
expressed in E. coli
assay
>95% (SDS-PAGE)
form
lyophilized powder
potency
0.03-0.1 μg/mL ED50
mol wt
7.9 kDa
packaging
pkg of 25 μg
storage condition
avoid repeated freeze/thaw cycles
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
mouse ... Ccl5(20304)
Application
RANTES has been shown to inhibit HIV-1 entry via human CCR-5 & also plays an important role in mediating immune and inflammatory responses.
Physical form
Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% trifluoroacetic acid containing 1.25 mg bovine serum albumin.
Analysis Note
The biological activity is measured by its ability to chemoattract 2 day cultured human monocytes.
Storage Class
13 - Non Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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T J Schall et al.
European journal of immunology, 22(6), 1477-1481 (1992-06-01)
The infiltration and activation of monocytes is a hallmark of chronic inflammation, including that associated with a variety of disease states such as rheumatoid arthritis, atherosclerosis, and various autoimmune conditions. Recently, a family of small molecular mass proteins has been
Zhongwen Zhang et al.
Stem cell research & therapy, 6, 36-36 (2015-04-19)
Unstable atherosclerotic plaques are prone to rupture, which leads to atherothrombosis. Endothelial progenitor cells (EPCs) are bone marrow-derived precursor cells that may repair vascular injury in atherosclerosis. Chemokine (C-C motif) receptor 5 (CCR5) promotes mobilization of EPCs. In this study
Anne C Solga et al.
Neoplasia (New York, N.Y.), 17(10), 776-788 (2015-11-21)
Solid cancers develop within a supportive microenvironment that promotes tumor formation and growth through the elaboration of mitogens and chemokines. Within these tumors, monocytes (macrophages and microglia) represent rich sources of these stromal factors. Leveraging a genetically engineered mouse model
Joseph L Sottnik et al.
Cancer research, 75(11), 2151-2158 (2015-04-10)
Cross-talk between tumor cells and their microenvironment is critical for malignant progression. Cross-talk mediators, including soluble factors and direct cell contact, have been identified, but roles for the interaction of physical forces between tumor cells and the bone microenvironment have
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