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R140

Sigma-Aldrich

Ro 04-6790 dihydrochloride

solid

Synonym(s):

4-Amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]benzenesulfonamide dihydrobromide

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About This Item

Empirical Formula (Hill Notation):
C12H16N6O2S · 2HCl
CAS Number:
202466-68-0
Molecular Weight:
381.28
MDL number:
MFCD11045584
UNSPSC Code:
12352202
PubChem Substance ID:
24278570
NACRES:
NA.77

form

solid

color

white

solubility

DMSO: >10 mg/mL
H2O: >10 mg/mL

originator

Roche

SMILES string

Cl.Cl.CNc1cc(NS(=O)(=O)c2ccc(N)cc2)nc(NC)n1

InChI

1S/C12H16N6O2S.2ClH/c1-14-10-7-11(17-12(15-2)16-10)18-21(19,20)9-5-3-8(13)4-6-9;;/h3-7H,13H2,1-2H3,(H3,14,15,16,17,18);2*1H

InChI key

QOAXXMSJHQHSFV-UHFFFAOYSA-N

Gene Information

human ... HTR6(3362)

Biochem/physiol Actions

Selective 5-HT6 serotonin receptor antagonist.

Features and Benefits

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Caution

Photosensitive

Legal Information

Manufactured and sold under license from Hoffman LaRoche.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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J C Bentley et al.
British journal of pharmacology, 126(7), 1537-1542 (1999-05-14)
1. The present study examined the effects of the selective 5-HT6 receptor antagonist 4-amino-N-(2, 6 bis-methylamino-pyrimidin-4-yl)-benzene sulphonamide (Ro 04-6790) on locomotor activity and unconditioned behaviour in male Sprague Dawley rats (230-300 g). 2. In non-quantified behavioural observations, animals treated with
A J Sleight et al.
British journal of pharmacology, 124(3), 556-562 (1998-07-01)
1. This study describes the in vitro characterization of two potent and selective 5-HT6 receptor antagonists at the rat and human recombinant 5-HT6 receptor. 2. In binding assays with [3H]-LSD, 4-amino-N-(2,6 bis-methylamino-pyrimidin-4-yl)-benzene sulphonamide (Ro 04-6790) and 4-amino-N-(2,6 bis-methylamino-pyridin-4-yl)-benzene sulphonamide (Ro
Bofan Yu et al.
Cell cycle (Georgetown, Tex.), 18(20), 2641-2650 (2019-08-15)
Noncoding RNAs play important roles in the progression of malignant tumors, including triple negative breast cancer (TNBC). Accumulating evidence supported the involvement of the oncogenic MUC1 in tumor metastasis. Our study aimed to explore the roles of miR-140-5p and MUC1

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