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R106

Sigma-Aldrich

Ro 16-6491 hydrochloride

solid

Synonym(s):

N-(2-Aminoethyl)-4-chlorobenzamide hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C9H11ClN2O · HCl
CAS Number:
94319-79-6
Molecular Weight:
235.11
MDL number:
MFCD00078595
UNSPSC Code:
12352200
PubChem Substance ID:
329823996

form

solid

color

white

mp

216-217 °C

solubility

H2O: soluble

SMILES string

Cl.NCCNC(=O)c1ccc(Cl)cc1

InChI

1S/C9H11ClN2O.ClH/c10-8-3-1-7(2-4-8)9(13)12-6-5-11;/h1-4H,5-6,11H2,(H,12,13);1H

InChI key

ARUMZUNJBHSOQQ-UHFFFAOYSA-N

Gene Information

human ... MAOB(4129)

Biochem/physiol Actions

Selective, reversible, orally-active MAO-B inhibitor which is devoid of indirect sympathomimetic activity.

comparable product

Product No.
Description
Pricing

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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E L Mullan et al.
Journal of neural transmission. Supplementum, 41, 307-311 (1994-01-01)
Ro 16-6491 is known to be a potent reversible inhibitor of human brain MAO-B. This compound and several analogues were tested for their effect on bovine liver MAO-B. It was found that in compounds where the amide bond of Ro
A M Cesura et al.
Journal of neurochemistry, 50(4), 1037-1043 (1988-04-01)
[3H]Ro 16-6491 [N-(2-aminoethyl)-p-chlorobenzamide HCl], a reversible "mechanism-based" inhibitor of monoamine oxidase (MAO) type B, binds selectively and with high affinity to the active site of MAO-B in brain and platelet membranes. Under normal conditions, the binding of [3H]Ro 16-6491 is
Interactions of the novel inhibitors of MAO-B Ro 19-6327 and Ro 16-6491 with the active site of the enzyme.
A M Cesura et al.
Pharmacological research communications, 20 Suppl 4, 51-61 (1988-12-01)
B Vallès et al.
Xenobiotica; the fate of foreign compounds in biological systems, 23(10), 1101-1111 (1993-10-01)
1. Moclobemide, an inhibitor of monoamine oxidase, shows mixed MAO A/B inhibition in rat, but pure MAO A inhibition in man. This is attributed to a primary amine metabolite which inhibits MAO B in vitro, but which is not detected
G P Bondiolotti et al.
Biochemical pharmacology, 50(1), 97-102 (1995-06-29)
To investigate whether the reversible monoamine oxidase-B (MAO-B) inhibitors lazabemide and Ro 16-6491 have any additional effect on monoamine uptake and release, in vitro experiments were performed on rat forebrain synaptosomes and blood platelets. The effects of the two drugs
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