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PZ0402

Sigma-Aldrich

PF-06807656

≥98% (HPLC)

Synonym(s):

(-)-3-(N-(4-Chlorophenyl)sulfamoyl)-4-methoxy-N-(1-(2-methyl-2H-1,2,3-triazol-4-yl)ethyl)benzamide

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5 MG
$52.42
25 MG
$249.00

About This Item

Empirical Formula (Hill Notation):
C19H20ClN5O4S
CAS Number:
2213468-04-1
Molecular Weight:
449.91
UNSPSC Code:
51111800
NACRES:
NA.77

$52.42

List Price$61.50Save 15%
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Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(NC(C1=NN(C)N=C1)C)C(C=C2S(=O)(NC3=CC=C(Cl)C=C3)=O)=CC=C2OC

InChI

1S/C19H20ClN5O4S/c1-12(16-11-21-25(2)23-16)22-19(26)13-4-9-17(29-3)18(10-13)30(27,28)24-15-7-5-14(20)6-8-15/h4-12,24H,1-3H3,(H,22,26)

InChI key

DERVNKULTWJINM-UHFFFAOYSA-N

Biochem/physiol Actions

PF-06807656 is a 3-sulfamoylbenzamide-based renal outer medullary potassium channel (ROMK, CCNJ1, Kir1.1) inhibitor (IC50 = 61 nM by whole cell patch clamp) that is insensitive to K80M or N171D pore mutation and exhibits high selectivity for human over rat species (IC50 against thallium sulfate/TlSO4-stimulated influx = 391 nM vs. >30 μM using human or rat ROMK1-expressing HEK293 cells; 82% vs. 0% inhibition by patch clamp using human or rat ROMK2-expressing HEK293 cells).

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Matthew F Sammons et al.
ACS medicinal chemistry letters, 9(2), 125-130 (2018-02-20)
Inhibitors of the renal outer medullary potassium channel (ROMK) show promise as novel mechanism diuretics, with potentially lower risk of diuretic-induced hypokalemia relative to current thiazide and loop diuretics. Here, we report the identification of a novel series of 3-sulfamoylbenzamide

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