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Key Documents

PZ0348

Sigma-Aldrich

NI-42

≥98% (HPLC)

Synonym(s):

4-Cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)benzenesulfonamide

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5 MG
$69.54
25 MG
$266.00

About This Item

Empirical Formula (Hill Notation):
C18H15N3O3S
CAS Number:
Molecular Weight:
353.40
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77

$69.54

List Price$73.20
Web-Only Promotion

Check Cart for Availability

Request a Bulk Order

Quality Level

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

room temp

SMILES string

CC1=CC2=CC(NS(=O)(C3=CC=C(C#N)C=C3)=O)=CC=C2N(C)C1=O

InChI

1S/C18H15N3O3S/c1-12-9-14-10-15(5-8-17(14)21(2)18(12)22)20-25(23,24)16-6-3-13(11-19)4-7-16/h3-10,20H,1-2H3

InChI key

BMVCSXFOQPYKKC-UHFFFAOYSA-N

Biochem/physiol Actions

NI-42 is a biased potent small molecule inhibitor of the bromodomain of the BRPF (bromodomain and PHD finger-containing) proteins, which are scaffolding proteins that assemble histone acetyltransferase (HAT) complexes of the MYST transcriptional coactivator family. NI-42 has an IC50 value of of 7.9 nM and is suitable for cellular and in vivo studies.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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