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PZ0258

Sigma-Aldrich

PF-06442609

≥98% (HPLC)

Synonym(s):

2-[(1S)-2-[4-Fluoro-2-[(1R)-2,2,2-trifluoro-1-methylethyl]phenoxy]-1-methylethyl]-3,4-dihydro-7-(4-methyl-1H-imidazol-1-yl)-2H-pyrido[1,2-a]pyrazine-1,6-dione, 2-[(2S)-1-{4-Fluoro-2-[(2R)-1,1,1-trifluoropropan-2-yl]phenoxy}propan-2-yl]-7-(4-methyl-1H-imidazol-1-yl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-dione, PF 06442609, PF06442609

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$291.00

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5 MG
$82.40
25 MG
$291.00

About This Item

Empirical Formula (Hill Notation):
C24H24F4N4O3
CAS Number:
Molecular Weight:
492.47
UNSPSC Code:
51111800
NACRES:
NA.77

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Quality Level

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

room temp

Biochem/physiol Actions

PF-06442609 is a potent γ secretase inhibitor that produces a robust reduction of brain Aβ42 and Aβ40 in in a guinea pig model. Apparently, PF-06442609 is suitable for rodent model of AD.

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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