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PZ0226

Sigma-Aldrich

CP 524515

≥98% (HPLC)

Synonym(s):

(2R,4S)-4-[[[3,5-Bis(trifluoromethyl)phenyl]methyl](methoxycarbonyl)amino]-2-ethyl-3,4-dihydro-6-(trifluoromethyl)-1(2H)-quinolinecarboxylic acid methylethyl ester

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About This Item

Empirical Formula (Hill Notation):
C27H27F9N2O4
CAS Number:
262352-13-6
Molecular Weight:
614.50
UNSPSC Code:
12352200
PubChem Substance ID:
329823780
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(OC(C)C)N1C2=CC=C(C(F)(F)F)C=C2[C@@H](N(CC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)C(OC)=O)C[C@H]1CC

InChI

1S/C27H27F9N2O4/c1-5-19-12-22(20-11-16(25(28,29)30)6-7-21(20)38(19)24(40)42-14(2)3)37(23(39)41-4)13-15-8-17(26(31,32)33)10-18(9-15)27(34,35)36/h6-11,14,19,22H,5,12-13H2,1-4H3/t19-,22+/m1/s1

InChI key

HFFFFTQVPXWDLI-KNQAVFIVSA-N

Biochem/physiol Actions

CP-524515 is a potent inhbitor of cholesteryl ester transfer protein (CETP) that leads to elevated high-density lipoprotein cholesterol levels. CP-532623 is structurally related to Torcetrapib (Cat. No. PZ0170).
CP-524515 is a potent inhbitor of cholesteryl ester transfer protein (CETP).

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
064M4711V

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Yingxue Cui et al.
Acupuncture in medicine : journal of the British Medical Acupuncture Society, 37(4), 237-243 (2019-05-30)
To investigate the anti-atherogenic effect of moxibustion and whether it is mediated through the reverse cholesterol transport process. 8-week-old male apolipoprotein E deficient (ApoE-/- knockout) mice were randomly divided into two groups (n=10 per group): atherosclerosis (AS) and AS plus

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