The epitope recognized by PLA0258 maps to a region between residue 524 and 574 of human cell division cycle 7 using the numbering given in entry NP_003494.1 (GeneID 8317).
Physical form
Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
Other Notes
Cell division cycle 7-related protein kinase (CDC7) is critical for the activation and firing of replication origins during S-phase. CDC7 kinase activity is activated and regulated by Dbf4. Substrates of CDC7 include the MCM (mini-chromosome maintenance) proteins, DNA polymerase alpha, Cdc45, Orc4, geminin and SV40 T-antigen. CDC7 has also been implicated to play a role in the DNA damage response.
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