The epitope recognized by PLA0256 maps to a region between residue 50 and 100 of human WD repeat domain 5 using the numbering given in entry NP_060058.1 (GeneID 11091).
WD-repeat domain 5 (WDR5) is a member of the WD repeat family. The WD repeat is defined by four or more repeating units of a conserved core of approximately 40 amino acids ending with tryptophan-aspartic acid (WD). WD repeats may serve as sites of protein-protein interaction for adaptor proteins and facilitate multiprotein complex formation. WDR5 contains 7 WD repeats and is a core subunit of the human MLL and SET1 histone H3 lys4 methyltransferase complexes. WDR5 functions in facilitating the assembly of MLL and SET1 chromatin-modifiying complexes.
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Frontiers in immunology, 9, 2615-2615 (2018-12-18)
Streptococcus suis (S. suis) ranks among the five most important porcine pathogens worldwide and occasionally threatens human health, particularly in people who come into close contact with pigs or pork products. An S. suis infection induces the formation of neutrophil
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