B23, NPM, member 1, nucleolar phosphoprotein B23, nucleolar protein NO38, nucleophosmin/nucleoplasmin family, numatrin, testicular tissue protein Li 128
The epitope recognized by PLA0252 maps to a region between residue 100 and 150 of human nucleophosmin using the numbering given in entry NP_002511.1 (GeneID 4869).
Nucleophosmin (NPM1) is involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors TP53/p53 and ARF. It associates with nucleolar ribonucleoprotein structures and binds single-stranded nucleic acids. NPM1 binds ribosomes presumably to drive ribosome nuclear export. Chromosomal aberrations involving NPM1 have been identified in several types of leukemia [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P06748].
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