PLA0196

Rabbit anti-STUB1/CHIP Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

• Synonym(s): CHIP, CLL-associated antigen KW-8, E3 ubiquitin protein ligase, HSPABP2, NY-CO-7, SCAR16, SDCCAG7, STIP1 homology and U box-containing protein 1, STIP1 homology and U-box containing protein 1, UBOX1, antigen NY-CO-7, carboxy terminus of Hsp70-interacting protein, heat shock protein A binding protein 2 (c-terminal), serologically defined colon cancer antigen 7
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• antibody form: affinity purified immunoglobulin
• antibody product type: primary antibodies
• grade: Powered by Bethyl Laboratories, Inc.
• species reactivity: mouse, human
• technique(s): immunoprecipitation (IP): 2-5 μg/mg; western blot: 1:2,000- 1:10,000
• accession no.: NP_005852.2
• shipped in: wet ice
• storage temp.: 2-8°C
• Gene Information: rabbit ... STUB1/CHIP(10273)

Description

Immunogen

The epitope recognized by PLA0196 maps to a region between residue 1 and 50 of human STIP1 homology and U-box containing protein 1 (carboxy terminus of Hsp70-interacting protein) using the numbering given in entry NP_005852.2 (GeneID 10273).

Physical form

Tris-buffered Saline containing 0.1% BSA containing 0.09% Sodium Azide

Other Notes

STUB1/CHIP is an E3 ubiquitin ligase and co-chaperone of heat-shock protein 70 (Hsp70). STUB1/CHIP interacts with Hsp70 to monitor protein folding and direct misfolded proteins for proteasomal degradation. It has been found to also associate with Hsp90 to remove phosphorylated protein tau, a protein that accumulates in the brains of Alzheimer′s and Down′s syndrome patients. STUB1/CHIP has been reported to also have intrinsic chaperone activity and recognize non-native proteins in response to heat stress. In this way, STUB1/CHIP has been shown to be a direct chaperone for p53.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable