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Key Documents

PLA0188

Sigma-Aldrich

Rabbit anti-HCF1 Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

Synonym(s):

C1 factor, CFF, HCF, HCF-1, HCF1, HFC1, MGC70925, MRX3, PPP1R89, VCAF, VP16 accessory protein, VP16-accessory protein, X-linked 3, host cell factor C1 (VP16-accessory protein), mental retardation, protein phosphatase 1, regulatory subunit 89

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

species reactivity

human

technique(s)

immunoprecipitation (IP): 2-5 μg/mg
western blot: 1:2,000- 1:10,000

accession no.

NP_005325.2

shipped in

wet ice

storage temp.

2-8°C

Gene Information

rabbit ... HCF1(3054)

General description

HCFC1 (host cell factor C1) is a coregulator of the zinc-finger transcription factor THAP11 (THAP domain containing 11). It is also called as RONIN. HCFC1 has a kelch domain with five kelch motifs, fibronectin-like domains, and an HCF-proteolysis domain with six HCF repeats. It is located on human chromosome X.

Immunogen

The epitope recognized by PLA0188 maps to a region between residue 1700 and 1750 of human host cell factor C1 (VP16-accessory protein) using the numbering given in entry NP_005325.2 (GeneID 3054).

Biochem/physiol Actions

HCFC1 interacts with various proteins to modulate several processes like the cell cycle, proliferation and transcription. It plays an important role in Ménière′s (MD) disease.

Physical form

Tris-buffered Saline containing 0.1% BSA containing 0.09% Sodium Azide

Other Notes

HCF1 was originally identified as a host-cell factor utilized by the herpes simplex virus to promote viral transcription. In the cell, HCF1 functions as a transcriptional co-regulator involved in the modification of histones and cell cycle progression.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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1

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Sequence variants in host cell factor C1 are associated with Meniere?s disease
Vrabec, et al.
Otology & Neurotology, 29(4), 561-561 (2008)
Hung-Chun Yu et al.
American journal of human genetics, 93(3), 506-514 (2013-09-10)
Derivatives of vitamin B12 (cobalamin) are essential cofactors for enzymes required in intermediary metabolism. Defects in cobalamin metabolism lead to disorders characterized by the accumulation of methylmalonic acid and/or homocysteine in blood and urine. The most common inborn error of

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