The epitope recognized by PLA0183 maps to a region between residue 466 and 516 of human death-associated protein 6 using the numbering given in entry NP_001341.1 (GeneID 1616).
Death-associated protein (DAXX) is a multifunctional protein originally identified as a FAS-interacting protein that modulates FAS-induced cell death. The involvement of DAXX in apoptosis has been difficult to understand, and its exact function in this process has only partially been elucidated. DAXX appears to also function as a transcriptional co-repressor and has been found to associate with the SNF2 chromatin-remodeling ATPase, alpha-thalassemia syndrome protein (ATRX), and modulate transcription.
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