PLA0173

Rabbit anti-CDC20 Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

• Synonym(s): CDC20 (cell division cycle 20, CDC20 cell division cycle 20 homolog, CDC20 cell division cycle 20 homolog (S. cerevisiae), CDC20A, S. cerevisiae, bA276H19.3, cell division cycle 20 homolog, cell division cycle 20 homolog (S. cerevisiae), homolog), p55CDC
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• antibody form: affinity purified immunoglobulin
• antibody product type: primary antibodies
• species reactivity: human, mouse
• technique(s): immunohistochemistry: 1:500- 1:2,000; immunoprecipitation (IP): 2-10 μg/mg; western blot: 1:2,000- 1:10,000
• accession no.: NP_001246.2
• UniProt accession no.: Q12834
• shipped in: wet ice
• storage temp.: 2-8°C
• target post-translational modification: unmodified
• Gene Information: rabbit ... CDC20(991)

Description

Immunogen

The epitope recognized by PLA0173 maps to a region between residue 449 and 499 of human cell division cycle 20 using the numbering given in entry NP_001246.2 (GeneID 991).

Physical form

Tris-buffered Saline containing 0.1% BSA containing 0.09% Sodium Azide

Other Notes

CDC20 is a WD repeat containing cell cycle-regulator that binds to and activates the ubiquitin-ligase activity of the APC/c (anaphase-promoting complex/cyclosome). APC/c ubiquitinating activity is responsible for the degradation of securin and cyclin B that prompts the onset of anaphase and exit from mitosis. CDC20 has also been reported to form a complex with histone deacetylases and can function as a transcriptional repressor involved in cell cycle arrest. As a regulator of APC/c activity, CDC20 plays a key role in the spindle-assembly checkpoint.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• flash_point_f: Not applicable
• flash_point_c: Not applicable