PLA0122

Rabbit anti-Chk2 Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

• Synonym(s): CDS1, CHK2, CHK2 (checkpoint; S.pombe) homolog, CHK2 checkpoint homolog, CHK2 checkpoint homolog (S. pombe), Checkpoint kinase 2, HuCds1, LFS2, PP1425, RAD53, bA444G7, cds1 homolog, checkpoint-like protein CHK2, hCds1
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• antibody form: affinity purified immunoglobulin
• antibody product type: primary antibodies
• species reactivity: human
• technique(s): immunoprecipitation (IP): 2-5 μg/mg; western blot: 1:2,000-1:10,000
• accession no.: NP_009125.1
• shipped in: wet ice
• Storage temp.: 2-8°C
• Gene Information: rabbit ... Chk2(11200)

Description

Immunogen

The epitope recognized by PLA0122 maps to a region between residues 1 and 50 of human Checkpoint Kinase 2 using the numbering given in entry NP_009125.1 (GeneID 11200).

Physical form

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

Other Notes

Chk2 functions as a checkpoint protein kinase in response to DNA damage to maintain genomic stability. The yeast homologs are Rad53 and Cds1. The two major upstream controllers of Chk2 are ATM and ATR which are part of the phosphatidylinositol 3-kinase family. When activated, Chk2 targets p53, BRCA1, Cdc25A and Cdc25C to cause cell cycle arrest.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable