PLA0103

Rabbit anti-CDK7 Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

• Synonym(s): 39 KDa protein kinase, CAK, CAK1, CDK-activating kinase 1, CDKN7, HCAK, MO15, STK1, Serine/threonine-protein kinase 1, TFIIH basal transcription factor complex kinase subunit, Xenopus laevis, cdk-activating kinase), cell division protein kinase 7, cyclin-dependent kinase 7 (MO15 homolog, cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase), homolog of Xenopus MO15 Cdk-activating kinase, kinase subunit of CAK, p39 Mo15, p39MO15, serine/threonine kinase stk1, serine/threonine protein kinase 1, serine/threonine protein kinase MO15
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• antibody form: affinity purified immunoglobulin
• antibody product type: primary antibodies
• species reactivity: mouse, human, rat
• technique(s): immunohistochemistry: 1:100-1:500; immunohistochemistry: 1:500-1:2,000; immunoprecipitation (IP): 2-10 μg/mg; western blot: 1:2,000-1:10,000
• accession no.: P50613
• UniProt accession no.: P50613
• shipped in: wet ice
• storage temp.: 2-8°C
• Gene Information: rabbit ... CDK7(1022)

Description

Immunogen

The epitope recognized by PLA0103 maps to a region between residues 300 and the C-terminus (residue 346) of human Cyclin-Dependent Kinase 7 using the numbering given in Swiss-Prot entry P50613 (GeneID 1022).

Physical form

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

Other Notes

Cyclin-dependent kinase 7 (CDK7) is a member of the CDK family of protein kinases that regulate cell cycle progression. CDK7 is the catalytic subunit in a trimeric complex with cyclin H and MAT1 that functions as a Cdk-activating kinase (CAK). CDK7 activates the kinase activities of CDK1, CDK2, CDK4, and CDK6 by threonine phosphorylation. In addition to its cell cycle function CDK7 has also been found to be an essential component of the transcription factor TFIIH. Several substrates of CDK7 are involved in transcription, further indicating a role in transcription.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable