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PLA0085

Sigma-Aldrich

Rabbit anti-Chk1 Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

Synonym(s):

1, CHK1, CHK1 (checkpoint; S.pombe) homolog, CHK1 checkpoint homolog, CHK1 checkpoint homolog (S. pombe), Checkpoint, Chk1-S, S. pombe, cell cycle checkpoint kinase, checkpoint kinase-1, homolog of

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

$558.00

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biological source

rabbit

Quality Level

100

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

species reactivity

human

technique(s)

immunohistochemistry: 1:1,000- 1:5,000
immunoprecipitation (IP): 2-10 μg/mg
western blot: 1:1,000-1:5,000

accession no.

O14757

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

rabbit ... Chk1(1111)

Immunogen

The epitope recognized by PLA0085 maps to a region between residues 250 and 300 of human Checkpoint Kinase 1 using the numbering given in SwissProt entry O14757 (GeneID 1111).

Physical form

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

Other Notes

Chk1 functions as a checkpoint protein kinase that is critical to the regulation of the Cdc25a and Cdc25c phosphatases that promote S and G2/M phase progression, respectively. Chk1 kinase activity inhibits cell cycle progression in the presence of DNA damage by phosphorylating Cdc25a and Cdc25c and causing the degradation of Cdc25a and cytoplasmic sequestration of Cdc25c.

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Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

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1

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Zheng-Wen Nie et al.
Cell cycle (Georgetown, Tex.), 16(22), 2220-2229 (2017-09-22)
Checkpoint 1 (Chk1), as an important member of DNA replication checkpoint and DNA damage response, has an important role during the G2/M stage of mitosis. In this study, we used porcine oocyte as a model to investigate the function of

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