CAP-E, CAPE, SMC protein 2, SMC-2, SMC2 (structural maintenance of chromosomes 2; yeast)-like 1, SMC2 structural maintenance of chromosomes 2-like 1 (yeast), SMC2L1, XCAP-E homolog, chromosome-associated protein E, hCAP-E, structural maintenance of chromosomes (SMC) family member
The epitope recognized by PLA0018 maps to a region between residue 1150 and the C-terminus (residue 1197) of human Structural Maintenance of Chromosomes 2 using the numbering given in entry NP_006435.1 (GeneID 10592).
Physical form
Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% sodium azide
Other Notes
Structural maintenance of chromosomes (SMC) proteins are part of the cohesin and condensin multisubunit complexes that play a critical role in chromosome organization, segregation, gene regulation, and DNA repair. The core condensin complex includes a heterodimer of SMC2 and SMC4 that functions to create positively supercoiled loops for chromatin condensation and metaphase chromatid shaping. A function for condensin in the DNA damage checkpoint response and gene repression has also been suggested.
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