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P9809

Sigma-Aldrich

Pancreastatin Fragment 37-52 human

≥97% (HPLC)

Synonym(s):

Chromograinin A fragment 286-301

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About This Item

Empirical Formula (Hill Notation):
C78H123N21O27S
CAS Number:
133605-57-9
Molecular Weight:
1819.00
MDL number:
MFCD00080083
UNSPSC Code:
12352202
PubChem Substance ID:
24898924

assay

≥97% (HPLC)

form

powder

UniProt accession no.

P10645

storage temp.

−20°C

SMILES string

CSCCC(NC(=O)C(CCC(O)=O)NC(=O)C(CCC(O)=O)NC(=O)C(CCC(O)=O)NC(=O)C(CCC(O)=O)NC(=O)C(N)CCC(O)=O)C(=O)NC(C)C(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)N1CCCC1C(=O)NC(CCC(N)=O)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(Cc2ccccc2)C(=O)NC(CCCNC(N)=N)C(=O)NCC(N)=O

InChI

1S/C78H123N21O27S/c1-38(2)34-51(73(122)96-52(35-42-14-10-9-11-15-42)74(123)90-44(16-12-31-84-78(82)83)66(115)85-36-55(81)101)88-56(102)37-86-67(116)45(19-24-54(80)100)95-75(124)53-17-13-32-99(53)77(126)63(40(5)6)98-76(125)62(39(3)4)97-64(113)41(7)87-68(117)50(30-33-127-8)94-72(121)49(23-29-61(111)112)93-71(120)48(22-28-60(109)110)92-70(119)47(21-27-59(107)108)91-69(118)46(20-26-58(105)106)89-65(114)43(79)18-25-57(103)104/h9-11,14-15,38-41,43-53,62-63H,12-13,16-37,79H2,1-8H3,(H2,80,100)(H2,81,101)(H,85,115)(H,86,116)(H,87,117)(H,88,102)(H,89,114)(H,90,123)(H,91,118)(H,92,119)(H,93,120)(H,94,121)(H,95,124)(H,96,122)(H,97,113)(H,98,125)(H,103,104)(H,105,106)(H,107,108)(H,109,110)(H,111,112)(H4,82,83,84)

InChI key

RLWQXZBLTNWVHR-UHFFFAOYSA-N

Gene Information

human ... CHGA(1113)

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Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
031M1592V
117K1221
103K1255
073K0564

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K B Helle et al.
Cellular and molecular life sciences : CMLS, 64(22), 2863-2886 (2007-08-25)
Chromogranin A (CgA) belongs to the granin family of uniquely acidic secretory proteins co-stored and co-secreted with other hormones and peptides in elements of the diffuse neuroendocrine system. The granins arise from different genes and are characterized by numerous sites
Osamu Nagakawa et al.
Urology, 62(3), 553-558 (2003-08-30)
To investigate the effect of various chromogranin A (CgA) fragments on the invasion, haptotactic migration, and growth of prostate cancer cells. We investigated the effect of five kinds of CgA fragments (79-115, 286-301, 324-341, 344-374, and 356-374) on the invasion
Víctor Sánchez-Margalet et al.
Regulatory peptides, 161(1-3), 8-14 (2010-02-27)
Pancreastatin is one of the regulatory peptides derived from intracellular and/or extracellular processing of chromogranin A, the soluble acidic protein present in the secretory granules of the neuroendocrine system. While the intracellular functions of chromogranin A include formation and maturation
O Nagakawa et al.
Cancer letters, 147(1-2), 207-213 (2000-02-05)
We investigated the effect of chromogranin A (pancreastatin) fragment on the invasion of PC-3, DU-145 and LNCaP prostate cancer cells through a reconstituted basement membrane (Matrigel) using a Transwell cell culture chamber assay. Chromogranin A fragment increased the invasive capacity

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