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P9797

Pyridostigmine bromide

≥98% (HPLC), Acetylcholinesterase inhibitor, solid

Synonym(s):

3-(Dimethylaminocarbonyloxy)-1-methylpyridinium bromide

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About This Item

Empirical Formula (Hill Notation):
C9H13BrN2O2
CAS Number:
101-26-8
Molecular Weight:
261.12
NACRES:
NA.77
PubChem Substance ID:
24277865
UNSPSC Code:
12352200
EC Number:
202-929-9
MDL number:
MFCD00079283
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100

Key Documents

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Product Name

Pyridostigmine bromide,

InChI key

VNYBTNPBYXSMOO-UHFFFAOYSA-M

InChI

1S/C9H13N2O2.BrH/c1-10(2)9(12)13-8-5-4-6-11(3)7-8;/h4-7H,1-3H3;1H/q+1;/p-1

SMILES string

[Br-].CN(C)C(=O)Oc1ccc[n+](C)c1

assay

≥98% (HPLC)

form

solid

solubility

water: 100 mg/mL, clear to very slightly hazy, colorless

originator

Valeant

Quality Level

100

Gene Information

human ... ACHE(43)

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This Item
1586009P4099900BP1033
Pyridostigmine bromide

Sigma-Aldrich

P9797

Pyridostigmine bromide

Pyridostigmine bromide United States Pharmacopeia (USP) Reference Standard

USP

1586009

Pyridostigmine bromide

Pyridostigmine bromide European Pharmacopoeia (EP) Reference Standard

P4099900

Pyridostigmine bromide

Pyridostigmine bromide British Pharmacopoeia (BP) Reference Standard

BP1033

Pyridostigmine bromide

form

solid

form

-

form

-

form

solid

assay

≥98% (HPLC)

assay

-

assay

-

assay

-

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

-

solubility

water: 100 mg/mL, clear to very slightly hazy, colorless

solubility

-

solubility

-

solubility

-

originator

Valeant

originator

-

originator

-

originator

-

Gene Information

human ... ACHE(43)

Gene Information

human ... ACHE(43)

Gene Information

human ... ACHE(43)

Gene Information

human ... ACHE(43)

Application

Pyridostigmine bromide has been used as a cholinesterase inhibitor in mice,[1] in florimetric assay for acetylcholine secretion[2] and for measuring acetylcholine release from mice atrial tissue.[3]

Biochem/physiol Actions

Acetylcholinesterase inhibitor.
Pyridostigmine bromide inhibits acetylcholine esterase and is membrane impermeable. It is used as a preventive medicine in chemical warfare.[4] Pyridostigmine bromide is a carbamate compound comprising quaternary amine structure. It displays low absorption at the gastrointestinal tract.[5] Sustained release of pyridostigmine is recommended for improving its bioavailability in treating myasthenia gravis.[6]

Features and Benefits

This compound was developed by Valeant. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Skin Sens. 1

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

flash_point_f

No data available

flash_point_c

No data available

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Certificates of Analysis (COA)

Lot/Batch Number
MKCH3765
MKBZ1795V
SLBH7204V
SLBH7203V
SLBB7904V

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Cardiomyocyte-secreted acetylcholine is required for maintenance of homeostasis in the heart
Roy A, et al.
Faseb Journal, 27(12), 5072-5082 (2013)
Cardiac acetylcholine inhibits ventricular remodeling and dysfunction under pathologic conditions
Roy A, et al.
Faseb Journal, 30(2), 688-701 (2015)
Gulf War and health Depleted uranium, pyridostigmine bromide, sarin, and vaccines (2000)
H Zach et al.
European journal of neurology, 20(4), 708-713 (2013-01-03)
Several small retrospective studies have observed that patients with a purely ocular manifestation of myasthenia gravis (MG) are significantly less likely to convert to a generalized disease when treated early on with corticosteroids. However, given the limited number of reported
Benefits from sustained-release pyridostigmine bromide in myasthenia gravis: results of a prospective multicenter open-label trial
Sieb JP and Kohler W
Clinical Neurology and Neurosurgery, 112(9), 781-784 (2010)
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