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P9121

Sigma-Aldrich

Prolactin Receptor/Fc Chimera human

recombinant, expressed in mouse NSO cells, ≥90% (SDS-PAGE), lyophilized powder, suitable for cell culture

Synonym(s):

Lactotrophin, Luteotropic Hormone (LTH), Luteotropin, Mamotrophin, PRL

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About This Item

CAS Number:
9002-62-4
MDL number:
MFCD06412371
UNSPSC Code:
12352202

biological source

human

recombinant

expressed in mouse NSO cells

assay

≥90% (SDS-PAGE)

form

lyophilized powder

mol wt

~66 kDa by SDS-PAGE (reducing)
calculated mol wt ~51 kDa

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

UniProt accession no.

P16471

storage temp.

−20°C

Gene Information

human ... PRLR(5618)

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Analysis Note

The biological activity is measured by its ability to neutralize recombinant human prolactin-induced proliferation of Nb2-11 cells (rat lymphoma cell line).

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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P A Kelly et al.
Biochemical Society transactions, 29(Pt 2), 48-52 (2001-05-18)
Prolactin-receptor-deficient mice are a good model in which to study the various actions of prolactin. Female homozygous knockout mice are completely infertile and show a lack of mammary development, while hemizogotes are unable to lactate following their first pregnancy. Male
J M Boutin et al.
Molecular endocrinology (Baltimore, Md.), 3(9), 1455-1461 (1989-09-01)
Human PRL receptor cDNA clones from hepatoma (Hep G2) and breast cancer (T-47D) libraries were isolated by using a rat PRL receptor cDNA probe. The nucleotide sequence predicts a mature protein of 598 amino acids with a much longer cytoplasmic
P W Gout et al.
Cancer research, 40(7), 2433-2436 (1980-07-01)
A malignant Nb rat lymphoma which in vivo is stimulated by estrogens has been established in suspension culture. The cultured cells grew readily in Fischer's medium supplemented with fetal calf serum (10%) and 2-mercaptoethanol (10(-4) M). If horse serum was

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