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Key Documents

P8780

Sigma-Aldrich

Phorbol 12-retinoate 13-acetate

≥95%, powder

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About This Item

Empirical Formula (Hill Notation):
C42H56O8
CAS Number:
80188-99-4
Molecular Weight:
688.89
UNSPSC Code:
12352200
PubChem Substance ID:
24898977

assay

≥95%

form

powder

color

yellow

storage temp.

−20°C

SMILES string

CC1C(OC(=O)\C=C(C)\C=C\C=C(C)\C=C\C2=C(C)CCCC2(C)C)C3(OC(C)=O)C(C4C=C(CO)CC5(O)C(C=C(C)C5=O)C14O)C3(C)C

InChI

1S/C42H56O8/c1-24(16-17-31-26(3)15-12-18-38(31,7)8)13-11-14-25(2)19-34(45)49-37-28(5)41(48)32(35-39(9,10)42(35,37)50-29(6)44)21-30(23-43)22-40(47)33(41)20-27(4)36(40)46/h11,13-14,16-17,19-21,28,32-33,35,37,43,47-48H,12,15,18,22-23H2,1-10H3/b14-11+,17-16+,24-13+,25-19+/t28-,32+,33-,35-,37-,40-,41-,42-/m1/s1

InChI key

GTNCUWBKHZZECN-IXTPSRJDSA-N

Biochem/physiol Actions

Skin tumor promoter.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 2 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
065H0662

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Ying Liu et al.
Endocrinology, 149(7), 3512-3520 (2008-03-29)
cAMP is a major regulator of CRH transcription. However, receptors activating CRH neurons (alpha-adrenergic and glutamatergic) do not signal through cAMP, suggesting that calcium phospholipid-dependent signaling synergizes with small elevations of intracellular cAMP. To test this hypothesis, we examined the
Christina Krabbe et al.
Journal of neurochemistry, 110(6), 1908-1920 (2009-07-25)
Neural stem cells constitute a promising source of cells for transplantation in Parkinson's disease, but a protocol for controlled dopaminergic differentiation is not yet available. Here we investigated the effect of the anti-apoptotic protein Bcl-x(L) and oxygen tension on dopaminergic
Yun-Hoon Choung et al.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 268(6), 885-892 (2010-11-03)
It has been suggested that connexin (Cx) gap junction proteins act as tumor suppressors and green tea has a potential to prevent tumor development, however, the studies on their association with human keratinocytes were rare. We evaluated the effects of
Lina Ji et al.
Journal of Alzheimer's disease : JAD, 19(3), 829-838 (2010-02-17)
We have previously reported that gelsolin, an actin binding protein, regulates the fibrillization of amyloid-beta protein. We report here that the expression of cytoplasmic gelsolin (cgelsolin) was upregulated in a concentration-dependent manner when SH-SY5Y, PC-12, and HEK-293 cells were subjected
Carsten Müller et al.
Journal of medicinal food, 14(1-2), 34-39 (2010-12-07)
Vineatrol®30 (developed and produced jointly by Breko GmbH [Bremen, Germany] and Actichem [Montauban, France]) is a grapevine-shoot extract that contains resveratrol as well as considerable amounts of resveratrol oligomers. In the present study it is shown that Vineatrol30 at a
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