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P7872

Sigma-Aldrich

Anti-Prostaglandin D2 Receptor antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

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About This Item

MDL number:
MFCD06798519
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

availability

not available in Japan

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 4-7 μg/mL using colon epithelium

UniProt accession no.

Q13258

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... PTGDR(5729)
mouse ... Ptgdr(19214)
rat ... Ptgdrl(63889)

General description

Prostaglandin D2 receptor (PTGDR) is encoded by the gene mapped to human chromosome 14q22.1. This receptor is mainly localized on immune cells. In addition, it is also expressed in platelets, cells of the central nervous system, ciliated and non-ciliated bronchial cells and alveolar epithelial type I and type II cells.

Immunogen

synthetic peptide corresponding to the third extracellular loop of human protaglandin D2 receptor. The immunizing peptide has ~80% homology with both the rat and mouse gene.

Biochem/physiol Actions

Prostaglandin D2 receptor (PTGDR) gene acts as a promising target for DNA methylation in advanced types of neuroblastoma (NB). The encoded protein is implicated in pulmonary vasodilation, bronchoconstriction, recruitment of eosinophils, basophils and T-lymphocytes. In addition, it also stimulates the synthesis of leukotriene C4. The gene expression has been associated with asthma.

Target description

Prostaglandin D2 Receptor gene encodes a protein that is a G-protein-coupled receptor. It has been shown to function as a prostanoid DP receptor. The activity of this receptor is mainly mediated by G-S proteins that stimulate adenylate cyclase

Physical form

Solution in phosphate buffered saline, pH 7.7, containing 0.1% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
SLCB0511
SLBZ4357
120M1254
129K1202
096K1546

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Polymorphisms of the PTGDR and LTC4S influence responsiveness to leukotriene receptor antagonists in Korean children with asthma.
Kang M J, et al.
Journal of Human Genetics, 56(4), 284-284 (2011)
Epigenetic silencing of prostaglandin E receptor 2 (PTGER2) is associated with progression of neuroblastomas.
Sugino Y, et al.
Oncogene, 26(53), 7401-7401 (2007)
PTGDR gene expression and response to dexamethasone treatment in an in vitro model.
Marcos-Vadillo E, et al.
PLoS ONE, 12(10), e0186957-e0186957 (2017)

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