P7291
Anti-Thromboxane B2 antibody produced in rabbit
whole antiserum, lyophilized powder
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About This Item
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
whole antiserum
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
contains
0.01% sodium azide
species reactivity
human
technique(s)
radioimmunoassay: suitable
UniProt accession no.
storage temp.
2-8°C
target post-translational modification
unmodified
Gene Information
human ... PTGS1(5742)
General description
Prostaglandin G/H synthase 1 (PTGS1)/Cyclooxygenase-1 (COX-1) is an enzyme that is expressed in the stomach, kidney and platelets. This gene is located on human chromosome 9q32−q33.3 and has 11 exons.
Immunogen
thromboxane B2-BSA.
Biochem/physiol Actions
Cyclooxygenase-1 (COX-1/PTGS1) helps to convert arachidonic acid to prostaglandin H2. It plays an important role in inflammation, pain, arthritic disease and cancer. PTGS1 helps to maintain renal blood flow and modulates platelet aggregation. It also protects gastric mucosa.
Physical form
The product is provided as a pre-diluted antiserum that has been lyophilized from a solution containing 0.01% sodium azide as a preservative.
Reconstitution
For a working dilution of 1:10, reconstitute with 5 mL buffer containing 0.01 M phosphate buffered saline, pH 7.4, 0.1% bovine serum albumin, and 0.1% sodium azide.
Storage and Stability
Prior to reconstitution, store at 2-8 °C.
After reconstitution:
1. Stock Solution: Separate into aliquots and freeze. Repeated freezing and thawing is not recommended
2. Working Solution: Discard if unused within 12 hours.
After reconstitution:
1. Stock Solution: Separate into aliquots and freeze. Repeated freezing and thawing is not recommended
2. Working Solution: Discard if unused within 12 hours.
Analysis Note
Tests per vial and specificity are determined using a dextran coated charcoal radioimmunoassay (RIA).
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Identification and functional characterization of polymorphisms in human cyclooxygenase-1 (PTGS1)
Lee CR, et al.
Pharmacogenetics and Genomics, 17(2), 145-145 (2007)
Inhibition of PTGS1 promotes osteogenic differentiation of adipose-derived stem cells by suppressing NF-kB signaling
Wang Y, et al.
Stem Cell Research & Therapy, 10(1), 1-10 (2019)
T Mahmud et al.
Gut, 43(6), 775-782 (1998-11-21)
Non-steroidal anti-inflammatory drugs (NSAIDs) cause gastrointestinal damage by a non-prostaglandin (PG) dependent "topical" action and by inhibiting cyclooxygenase. To discriminate between these two effects by studying some key pathophysiological steps in NSAID enteropathy following administration of (R)- and (S)-flurbiprofen, the
L Pelligand et al.
BMC veterinary research, 11, 296-296 (2015-12-05)
The role of cyclooxygenase(COX)-1 and COX-2 in the saluretic and renin-angiotensin responses to loop diuretics in the cat is unknown. We propose in vivo characterisation of isoform roles in a furosemide model by administering non-steroidal anti-inflammatory drugs (NSAIDs) with differing
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