The conjugates will identify and quantitate cells containing intracellular forms of human IL-4.
Immunogen
recombinant human IL-4
Biochem/physiol Actions
Interleukin-4 (IL-4) is a T cell derived chemokine that stimulates the Th2 mediated immune response and proliferation of B cells. The effects of IL-4 are mediated by two types of receptors, type I receptor consisting of IL-4Rα and common γ chain and type II receptor composed of IL-4Rα and IL-13Rα1. The signaling stimulated by IL-4 leads to activation of JAK/STAT6 and IRS-mediated PI3K/Akt pathway. IL-4 is responsible for endocytic activity of macrophages, chemotaxis of leukocytes in response to inflammation, angiogenesis and regulation of nitric oxide metabolism in macrophages. Conjugation of R-Phycoerythrin to the antibody enables its use in immunofluorescent techniques.
Physical form
25 μg of antibody in 1.0 mL of saline containing up to 0.5% bovine serum albumin. Contains 0.1% sodium azide as a preservative.
Preparation Note
Purified antibody is conjugated to R-phycoerythrin (PE).
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