P6614

Anti-phospho-Pyk2 (pTyr⁴⁰²) antibody produced in rabbit

affinity isolated antibody, buffered aqueous glycerol solution

• MDL number: MFCD03455760
• UNSPSC Code: 12352203
• NACRES: NA.44

Properties

• biological source: rabbit
• Quality Level: 200
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous glycerol solution
• mol wt: antigen ~116 kDa
• species reactivity: human, rat, chicken
• technique(s): western blot: 1:1,000 using chick embryo fibroblasts (CEF) cells expressing human Pyk2
• UniProt accession no.: Q14289
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pTyr402)
• Gene Information: human ... PTK2B(2185) ; rat ... Ptk2b(50646)

Description

General description

Pyk2 (proline-rich kinase 2) is a protein that belongs to Tyr protein kinase family and is expressed in mesenchymal cells, epithelial cells, endothelial cells, neonatal cardiomyocytes, osteoclasts and neuronal cells. It has a crucial role in T and B cell antigen receptor signaling, cell cycle progression, metastasis, and NK cytotoxicity. It also modulates ion channel function and neuronal short- and long- term responses. Anti-phospho-Pyk2 (pTyr⁴⁰²) antibody can be used in western blotting (1:1,000). Rabbit anti-phospho-Pyk2 (pTyr⁴⁰²) antibody reacts specifically with Pyk2 (pTyr⁴⁰²) (116 kD approx.) of rat, chicken and human.

Immunogen

synthetic phosphopeptide derived from the region of Pyk 2 that contains tyrosine 402.

Application

Anti-phospho-Pyk2 (pTyr⁴⁰²) antibody can be used in immunoblotting (diluted 1: 1000).

Packaging

One vial is sufficient for 10 immunoblots.

Physical form

solution in Dulbecco′s phosphate buffered saline (without Mg²⁺ and Ca²⁺), pH 7.3, containing 50% glycerol, 1.0 mg/ml BSA (IgG and protease free) and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids