Parkin RBR E3 ubiquitin protein ligase (PARK2) is a putative tumor suppressor gene. It possesses an amino-terminal region containing the Ubl (ubiquitin like) domain and a carboxy-terminal region with four zinc coordinating domains, that is, RING0, RING1, in between ring (IBR) and RING2. Parkin is a 465 amino acid protein which is part of the ubiquitin-proteasome system that targets proteins for degradation. The gene encoding it is localized on human chromosome 6q25.2-q27.
Immunogen
synthetic peptide CI(298)KELHHFRILGEEQYN(313), corresponding to amino acid residues 298-313 from human parkin. The sequence is completely conserved between human, mouse, and rat.
Application
Anti-Parkin antibody produced in rabbit has been used in Western blotting and immunohistochemistry.
Biochem/physiol Actions
The expression of parkin RBR E3 ubiquitin protein ligase has been found to be altered in various malignancies. Mutations in the gene encoding it have been linked to autosomal recessive juvenile Parkinson (ARJP) disease. Parkin has a neuroprotective E3 ligase activity and polyubiquitylates proteins before degradation.
Physical form
Solution of 100 μg (1 mg/mL) in phosphate buffered saline containing 1.0 mg/mL BSA and 0.05% sodium azide.
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Cerebral ischemia-reperfusion (I-R) is a complex pathological process. Although autophagy can be evoked by ischemia, its involvement in the reperfusion phase after ischemia and its contribution to the fate of neurons remains largely unknown. In the present investigation, we found
PARK2 polymorphisms predict disease progression in patients infected with hepatitis C virus.
Al-Qahtani AA
Annals of Hepatology (2016)
Endoplasmic reticulum stress induced by tunicamycin and thapsigargin protects against transient ischemic brain injury
Xiangnan Z
Autophagy (2014)
Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance
Xiangnan Zhang
Autophagy (2013)
Genetic and epigenetic alterations affecting PARK-2 expression in cervical neoplasm among North Indian patients.
Naseem A
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine (2017)
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