Monoclonal Anti-γ Parvin (mouse IgG1 isotype) is derived from the gparvin 40 hybridoma produced by the fusion of mouse myeloma cells (NS1) and splenocytes from BALB/c mice. The parvin protein family belongs to the focal adhesion proteins. This family of proteins consists of three members α, β and γ parvin. γ parvin is expressed in lymphoid tissues. Parvin γ (PARVG) gene is located on human chromosome 22q13.31.
Specificity
Monoclonal Anti-γ Parvin recognizes human, monkey, and bovine γ parvin. It does not recognize mouse or rat γ parvin.
Immunogen
peptide corresponding to the C-terminal region of human γ parvin (amino acids 314-328).
Application
Monoclonal Anti-γ Parvin antibody produced in mouse may be used in enzyme-linked immunosorbent assay (ELISA) and immunoblotting.
Biochem/physiol Actions
Monoclonal antibodies specific for γ parvin (PARVG) are an important tool for studying the biology of focal adhesion proteins. PARVG gene may have decreased expression in some cancer lines.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Storage and Stability
For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots at −20 °C. Repeated freezing and thawing is not recommended. Storage in frost-free freezers is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Parvin-beta inhibits breast cancer tumorigenicity and promotes CDK9-mediated peroxisome proliferator-activated receptor gamma 1 phosphorylation
Johnstone CN, et al.
Molecular and Cellular Biology, 28(2), 687-704 (2008)
Parvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamily
Olski TM, et al.
Journal of Cell Science, 114(3), 525-538 (2001)
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