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P5523

Sigma-Aldrich

Phe-Leu-Glu-Glu-Leu

≥97% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C31H47N5O10
CAS Number:
69729-06-2
Molecular Weight:
649.73
MDL number:
MFCD00076877
UNSPSC Code:
12352200
PubChem Substance ID:
24898663
NACRES:
NA.26

assay

≥97% (HPLC)

form

powder

storage temp.

−20°C

SMILES string

CC(C)CC(NC(=O)C(CCC(O)=O)NC(=O)C(CCC(O)=O)NC(=O)C(CC(C)C)NC(=O)C(N)Cc1ccccc1)C(O)=O

InChI

1S/C31H47N5O10/c1-17(2)14-23(35-27(41)20(32)16-19-8-6-5-7-9-19)30(44)34-21(10-12-25(37)38)28(42)33-22(11-13-26(39)40)29(43)36-24(31(45)46)15-18(3)4/h5-9,17-18,20-24H,10-16,32H2,1-4H3,(H,33,42)(H,34,44)(H,35,41)(H,36,43)(H,37,38)(H,39,40)(H,45,46)

InChI key

JNBCIUTTWUUDDX-UHFFFAOYSA-N

Substrates

Substrate for vitamin K-dependent carboxylation studies.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
025K12441
025K1244
054K10071
113K0628
113K06281

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Synthesis of two analogs of a cyclic hexapeptide with disulfide bridge corresponding to bovine prothrombin precursor sequence 18-23. Extent of carboxylation by Vitamin K-Dependent carboxylase.
Rich DH, Kawai M, Goodman HL, Suttie JW.
International Journal of Peptide and Protein Research, 18, 41-51 (1081)
Vitamin K-dependent carboxylase: purification of the rat liver microsomal enzyme.
L M Canfield et al.
Archives of biochemistry and biophysics, 202(2), 515-524 (1980-07-01)
D H Rich et al.
FEBS letters, 152(1), 79-82 (1983-02-07)
Liver microsomes contain a vitamin K and O2-dependent carboxylase that converts peptide-bound glutamyl residues to gamma-carboxyglutamate residues. The peptide Boc-O-phospho-Ser-O-phospho-Ser-Leu-OMe has now been synthesized. This peptide inhibits the carboxylation of endogenous protein precursors by a detergent-solubilized preparation of the carboxylase
J M Girardot
The Journal of biological chemistry, 257(24), 15008-15011 (1982-12-25)
The vitamin K-dependent carboxylase extracted from rat liver microsomes by 3-([3-cholamidopropyl] dimethylammoniol)-1-propane sulfonate detergent solution has been partially purified by chromatography on Ultrogel AcA-34 followed by carboxymethyl-Sepharose chromatography and pentapeptide affinity chromatography. The carboxylase appears to be composed of two
L J Van Haarlem et al.
The Biochemical journal, 245(1), 251-255 (1987-07-01)
Vitamin K-dependent carboxylase activity has been demonstrated in the crude microsomal fraction of the intima of bovine aortae. The procedure for the isolation of vessel wall carboxylase is a slight modification of the general preparation procedure for tissue microsomes. The
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