P4855
Poly(ADP-ribose) Polymerase Automodified bovine
solution
Synonym(s):
PARP
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About This Item
form
solution
Application
Positive control for immunoblotting techniques. A streak of M.W. > 116 kDa is detected by immunoblotting, representing PARP modified to various extents by poly(ADP-ribose). Recommended use: 5-20 μl per gel lane.
Other Notes
Partially purified bovine PARP, automodified by the addition of NAD and necessary cofactors.
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inhibitor
Product No.
Description
Pricing
signalword
Danger
Hazard Classifications
Acute Tox. 4 Dermal - Aquatic Chronic 3 - Eye Dam. 1 - Repr. 2 - Skin Sens. 1
Storage Class
10 - Combustible liquids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Carla O Contreras-Ochoa et al.
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Toxoplasma gondii invades any nucleated cell, but different replication speed and effects on survival/apoptosis processes have been found depending on cell type. There are scarce and controversial results regarding the effect of this parasite on host cell apoptosis within the
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Platinum-based chemotherapy is the most common treatment for patients with advanced non-small cell lung cancer (NSCLC). Genetic polymorphisms in the base excision repair (BER) pathway are suspected to influence the response of patients to this type of therapy. In this
Tomoharu Osada et al.
Biochemical and biophysical research communications, 434(1), 15-21 (2013-04-04)
We examined the roles of poly(ADP-ribosylation) in chromatin remodeling during the first cell cycle of mouse embryos. Drug-based inhibition of poly(ADP-ribosylation) by a PARP inhibitor, PJ-34, revealed up-regulation of dimethylation of histone H3 at lysine 4 in male pronuclei and
Sheng-Yi Yu et al.
Chemico-biological interactions, 203(2), 412-422 (2013-03-26)
Gefitinib, a tyrosine kinase inhibitor of the epidermal growth factor receptor (EGFR), has been used to treat numerous cancers; however, evidence has shown that cancer cells can become resistant to gefitinib during therapy. Here, we report a human proto-oncogene, securin
Karen L Cooper et al.
Toxicology and applied pharmacology, 269(2), 81-88 (2013-03-26)
Arsenic is a recognized human carcinogen and there is evidence that arsenic augments the carcinogenicity of DNA damaging agents such as ultraviolet radiation (UVR) thereby acting as a co-carcinogen. Inhibition of DNA repair is one proposed mechanism to account for
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