All Photos(1)

Key Documents

COO/COA

View All Documentation

P4725

L-α-Phosphatidyl-D-myo-inositol 3,4-diphosphate, dioctanoyl

Name: <SC>L</SC>-α-Phosphatidyl-<SC>D</SC>-<I>myo</I>-inositol 3,4-diphosphate, dioctanoyl
Brand: SIGMA

Sign Into View Organizational & Contract Pricing

All Photos(1)

About This Item

Empirical Formula (Hill Notation):

C₂₅H₄₉O₁₉P₃

Molecular Weight:

746.57

MDL number:

MFCD02259149

UNSPSC Code:

12352207

PubChem Substance ID:

24898494

NACRES:

NA.77

This product is discontinued. Contact Technical Servicefor assistance.

form

powder

solubility

H₂O: soluble

Storage temp.

−20°C

SMILES string

CCCCCCCC(=O)OC[C@H](COP(O)(=O)O[C@H]1[C@H](O)[C@@H](O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H]1O)OC(=O)CCCCCCC

InChI

1S/C25H49O19P3/c1-3-5-7-9-11-13-18(26)39-15-17(41-19(27)14-12-10-8-6-4-2)16-40-47(37,38)44-23-20(28)21(29)24(42-45(31,32)33)25(22(23)30)43-46(34,35)36/h17,20-25,28-30H,3-16H2,1-2H3,(H,37,38)(H2,31,32,33)(H2,34,35,36)/t17-,20-,21-,22+,23+,24+,25+/m1/s1

Inchi Key

XLNCEHRXXWQMPK-AWGZLWLLSA-N

Biochem/physiol Actions

Activates Ca²⁺-insensitive PKC isotypes δ, ε, and η, activates Akt (a serine-threonine kinase also known as PKBα) by direct interaction with the Akt pleckstrin homology domain.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Distinct phosphatidylinositol 3-kinase lipid products accumulate upon oxidative and osmotic stress and lead to different cellular responses.

J Van der Kaay et al.

The Journal of biological chemistry, 274(50), 35963-35968 (1999-12-10)

Signaling by phosphatidylinositol (PI) 3-kinases is mediated by 3-phosphoinositides, which bind to Pleckstrin homology (PH) domains that are present in a wide spectrum of proteins. PH domains can be classified into three groups based on their different lipid binding specificities.

Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3.

A Toker et al.

The Journal of biological chemistry, 269(51), 32358-32367 (1994-12-23)

The effect of phosphoinositides on the activity of protein kinase C (PKC) isotypes was investigated. PKC alpha, beta I, beta II, gamma, delta, epsilon, eta, and zeta were expressed in baculovirus-infected insect cells and purified by column chromatography. The calcium-activated

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate.

T F Franke et al.

Science (New York, N.Y.), 275(5300), 665-668 (1997-01-31)

The regulation of the serine-threonine kinase Akt by lipid products of phosphoinositide 3-kinase (PI 3-kinase) was investigated. Akt activity was found to correlate with the amount of phosphatidylinositol-3,4-bisphosphate (PtdIns-3,4-P2) in vivo, and synthetic PtdIns-3,4-P2 activated Akt both in vitro and

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service