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P4631

Sigma-Aldrich

Phosphodiesterase I from Bothrops atrox

Type V, crude dried venom, ≥0.01 unit/mg solid

Synonym(s):

5′-Exonuclease, Oligonucleate 5′-nucleotidohydrolase

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About This Item

Enzyme Commission number:
3.1.4.1 (BRENDA, IUBMB)
EC Number:
232-564-0
MDL number:
MFCD00131883
UNSPSC Code:
41106305
NACRES:
NA.32

type

Type V

form

crude dried venom

specific activity

≥0.01 unit/mg solid

storage temp.

−20°C

Unit Definition

One unit will hydrolyze 1.0 μmole of bis(p-nitrophenyl) phosphate per min at pH 8.8 at 37 °C.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
SLBS7264
SLBJ0499V
011M1528V
068K1410
018K1611

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Antonella Marucci et al.
Biochimica et biophysica acta, 1833(6), 1388-1395 (2013-03-19)
Ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) inhibits insulin signaling and action. Understanding the mechanisms underlying ENPP1 expression may help unravel molecular mechanisms of insulin resistance. Recent data suggest a role of ENPP1-3'untraslated region (UTR), in controlling ENPP1 expression. We sought to
Aurora Mejía-Benítez et al.
BMC medical genetics, 14, 21-21 (2013-02-05)
Recent genome wide association studies (GWAS) and previous positional linkage studies have identified more than 50 single nucleotide polymorphisms (SNPs) associated with obesity, mostly in Europeans. We aimed to assess the contribution of some of these SNPs to obesity risk
Ronald A Albright et al.
The Journal of biological chemistry, 289(6), 3294-3306 (2013-12-18)
NPP4 is a type I extracellular membrane protein on brain vascular endothelium inducing platelet aggregation via the hydrolysis of Ap3A, whereas NPP1 is a type II extracellular membrane protein principally present on the surface of chondrocytes that regulates tissue mineralization.
Nancy Côté et al.
European journal of pharmacology, 689(1-3), 139-146 (2012-06-05)
Calcific aortic valve disease is the most common heart valve disorder. So far, there is no medical treatment for calcific aortic valve disease. The expression of ectonucleotidases, which metabolize nucleotides into phosphate products, may influence the calcification of the aortic
N C W Mackenzie et al.
Bone, 51(5), 961-968 (2012-07-31)
The recent elucidation of rare human genetic disorders resulting from mutations in ectonucleotide pyrophosphotase/phosphodiesterase (ENPP1), also known as plasma cell membrane glycoprotein 1 (PC-1), has highlighted the vital importance of this molecule in human health and disease. Generalised arterial calcification
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