P3743
Anti-Pleiotrophin antibody produced in goat
affinity isolated antibody, lyophilized powder
Synonym(s):
Anti-PTN
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About This Item
biological source
goat
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
human
technique(s)
western blot: 0.1-0.2 μg/mL
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... PTN(5764)
General description
Pleiotrophin (PTN) is a heparin-binding growth factor, also known as heparin-binding growth-associated molecule, heparin affin regulatory peptide, heparin-binding growth factor-8, heparin-binding neurotrophic factor and osteoblast-specific factor. PTN expression is found during development in cells that are in early differentiation stage. The biological functions of PTN include cell migration, proliferation, angiogenesis and differentiation of neural progenitor cells growth of neuritis and fetal lung development. Cellular signalling of PTN is mediated by the receptor protein tyrosine phosphatase (RPTP) β/zeta and is important in tumor growth, angiogenesis and metastasis. Over expression of PTN is observed in neurodegenerative disorders, breast, prostate, lung cancers, glioblastoma, meningioma and melanoma
Anti-Pleiotrophin specifically recognizes human pleiotrophin.
Anti-Pleiotrophin specifically recognizes human pleiotrophin.
Immunogen
purified recombinant human pleiotrophin expressed in Sf 21 cells.
Application
Anti-Pleiotrophin antibody may be used for immunoblotting at a working concentration of 0.1-0.2 μg/ml. The antibody was used for ELISA at a working antibody dilution of 1:200 using cutaneous nerve protein extracts of female Lewis rats.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
11 - Combustible Solids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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A Höke et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 26(38), 9646-9655 (2006-09-22)
Schwann cell phenotype is classified as either myelinating or nonmyelinating. Additional phenotypic specialization is suggested, however, by the preferential reinnervation of muscle pathways by motoneurons. To explore potential differences in growth factor expression between sensory and motor nerve, grafts of
Tingting Weng et al.
Respiratory research, 11, 80-80 (2010-06-23)
Mammalian lung development is a complex biological process, which is temporally and spatially regulated by growth factors, hormones, and extracellular matrix proteins. Abnormal changes of these molecules often lead to impaired lung development, and thus pulmonary diseases. Epithelial-mesenchymal interactions are
Pablo Perez-Pinera et al.
Cell cycle (Georgetown, Tex.), 6(23), 2877-2883 (2007-12-25)
Pleiotrophin (PTN, Ptn) is a widely expressed, developmentally regulated 136 amino acid secreted heparin-binding cytokine. It signals through a unique signaling pathway; the PTN receptor is the transmembrane receptor protein tyrosine phosphatase (RPTP)beta/zeta. RPTPbeta/zeta is inactivated by PTN, which leads
Evangelia Papadimitriou et al.
European cytokine network, 20(4), 180-190 (2010-02-20)
Pleiotrophin (PTN) is a heparin-binding growth factor with diverse biological activities, the most studied of these being those related to the nervous system, tumor growth and angiogenesis. Although interest in the involvement of PTN in tumor growth is increasing, many
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