P3246

Pipamperone dihydrochloride

Name: Pipamperone dihydrochloride
Brand: SIGMA
Price: 286 USD

~99% (HPLC), dopamine receptor antagonist, powder

Synonym(s):

1′-[4-(4-Fluorophenyl)-4-oxobutyl]-[1,4′-bipiperidine]-4′-carboxamide dihydrochloride, R4050

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100 MG

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About This Item

Empirical Formula (Hill Notation):

C₂₁H₃₀N₃O₂F · 2HCl

CAS Number:

2448-68-2

Molecular Weight:

448.40

NACRES:

NA.77

PubChem Substance ID:

24724576

UNSPSC Code:

12352200

EC Number:

219-507-5

MDL number:

MFCD00242980

Assay:

~99% (HPLC)

Form:

powder

Quality level:

100

Key Documents

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Product Name

Pipamperone dihydrochloride, ~99% (HPLC), powder

assay

~99% (HPLC)

Quality Level

100

form

powder

color

white

solubility

H₂O: >2.0 mg/mL

originator

Johnson & Johnson

SMILES string

Cl[H].Cl[H].NC(=O)C1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)N3CCCCC3

InChI

1S/C21H30FN3O2.2ClH/c22-18-8-6-17(7-9-18)19(26)5-4-12-24-15-10-21(11-16-24,20(23)27)25-13-2-1-3-14-25;;/h6-9H,1-5,10-16H2,(H2,23,27);2*1H

InChI key

BMXXSXQVMCXGJM-UHFFFAOYSA-N

Related Categories

Bioactive Small Molecules

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1 of 4

This Item	PZ0362	SML0927	A2846
Sigma-Aldrich P3246 Pipamperone dihydrochloride	Sigma-Aldrich PZ0362 CP-640186 hydrochloride	Sigma-Aldrich SML0927 Diapocynin	Sigma-Aldrich A2846 A-134974 dihydrochloride hydrate
assay ~99% (HPLC)	assay ≥95% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form powder	form powder	form powder	form solid
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
solubility H₂O: >2.0 mg/mL	solubility H₂O: 2 mg/mL, clear (warmed)	solubility DMSO: 2 mg/mL, clear (warmed)	solubility H₂O: soluble
color white	color white to beige	color white to beige	color off-white to light tan
originator Johnson & Johnson	originator -	originator -	originator Abbott

Application

Pipamperone dihydrochloride may be used:

as an internal standard in liquid chromatography with coulometric detection
as an antipsychotic drugs to test its interaction with human ether-a-go-go-related gene (hERG) channel[1]
as an internal standard to spike human colostrum samples for reversed phase liquid chromatography- ultraviolet (LC-UV) analysis[2]

Biochem/physiol Actions

Pipamperone, a butyrophenone derivative is a pharmacological chaperone[3] and is a membrane-permeable dopamine receptor D4 (DRD4) antagonist.[4] The affinity of pipamperone is higher for DRD4 and 5-hydroxytryptamine 2A receptor (5-HT2A) in comparison with DRD2.[4] It may be useful therapeutic in treating behavioral disorders and psychomotor agitation symptoms.

D₂ dopamine receptor antagonist; 5-HT₂ serotonin receptor antagonist; antipsychotic.

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

wgk

WGK 1

pictograms

GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number

0000490771

0000476344

0000469940

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Quantification of piritramide in human colostrum.

A Van Eeckhaut et al.

Journal of clinical pharmacy and therapeutics, 42(3), 306-310 (2017-03-16)

In our university hospital (UZBrussel), one of the options to control post-operative pain after a Caesarean section under general anaesthesia is to administer piritramide by patient-controlled intravenous analgesia (PCIA). As no information is available about the possible transfer of this

Evaluation of serotonin-2A receptor occupancy with 123I-5-I-R91150 and single-photon emission tomography before and after low-dose pipamperone administration in the canine brain.

Kathelijne Peremans et al.

Nuclear medicine communications, 29(8), 724-729 (2008-08-30)

To conduct a cost-efficient pilot study on the effect of low-dose pipamperone on the serotonin-2A receptor binding in a large animal model with conventional single-photon emission tomography modalities. Three healthy drug-naive female Beagle dogs were scanned before and after administration

Identification and quantification of 30 antipsychotics in blood using LC-MS/MS.

Eva Saar et al.

Journal of mass spectrometry : JMS, 45(8), 915-925 (2010-07-22)

Over the last decade, the prescription rates of antipsychotic (AP) drugs have increased worldwide. Studies have shown that the risk of sudden cardiac death is threefold higher among patients treated with APs. To investigate the presence of APs in postmortem

The treatment of autism with pipamperone: A case report

Petrosino B, et al.

European Psychiatry : The Journal of the Association of European Psychiatrists, 33, S682-S682 (2016)

Is it possible to predict the clinical effects of neuroleptics from animal data? Part V: From haloperidol and pipamperone to risperidone.

P A Janssen et al.

Arzneimittel-Forschung, 44(3), 269-277 (1994-03-01)

In 1965 the first study of this series reported different effects of neuroleptics in rats, supporting clinical differences. At the one end, haloperidol presented as a potent and specific antagonist of the psychostimulants amphetamine and apomorphine. Haloperidol-like neuroleptics have marked

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Global Trade Item Number

SKU	GTIN
P3246-100MG	04061832092676

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